Parasympathomimetics

General properties[edit | edit source]

Parasympathomimetics mimic the effects that arise from irritation of the parasympathetic system. They are substances that act on three types of muscarinic receptors (M-receptors). Their effect is similar to acetylcholine. We can therefore also call them synergists of acetylcholine on M receptors. Most parasympathomimetics are non-selective substances that can be used in the therapy of certain diseases.

Types of parasympathomimetics[edit | edit source]

Parasympathomimetics can be divided into two large groups:

Direct parasympathomimetics – directly acting, stimulate M receptors
Indirect parasympathomimetics - acting indirectly, they block ACHE (acetylcholinesterase) and thereby increase the amount of neurotransmitter (ACH).

Effects[edit | edit source]

PSMs have the most pronounced effects in the area of smooth muscle. They are used to increase the tone and motility of the GIT. Indirectly acting PSMs improve the condition in myasthenia gravis.

Adverse effects[edit | edit source]

Adverse effects such as diarrhea , vomiting , nausea , stomach cramps, sweating, miosis, increased salivation may occur.

Contraindications[edit | edit source]

Do not use in case of obstruction of the urinary tract.

Links[edit | edit source]

References[edit | edit source]

HYNIE, Sixtus. Farmakologie v kostce. 2. edition. Triton, 2001. ISBN 80-7254-181-1.