Nikolsky's sign

Nikolsky's sign is a clinical dermatological sign. it is typical for pemphigus vulgaris and Toxic Epidermal Necrolysis / (Lyell's syndrome).

Types:

• direct: slight finger pressure on unaffected skin will cause skin efflorescence / erosion (this is due to The Binding of antibodies to desmosomes around the erosion).
• indirect: when pressing on the skin Bula, the bula spreads to the sides.

Literature used

• ŠTORK, Jiří. Dermatovenerologie. 2. edition. Galén, 2013. ISBN 978-80-7262-898-8.