Nelson syndrome

From WikiLectures

A relatively rare pituitary adenoma that occurs in patients after adrenal removal, which is increasingly producing ACTH. As a result of adrenalectomy, feedback inhibition of CRH by cortisol is lost , thus increasing hypothalamic CRH secretion and thus ACTH overproduction.

The first symptoms may include visual field loss and hyperpigmentation.

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  • KLENER, Pavel. Vnitřní lékařství. 4. edition. Praha : Galén : Karolinum, c2011. 1174 pp. ISBN 978-80-7262-705-9.
  • VOKURKA, Martin – HUGO, Jan, et al. Velký lékařský slovník [online] 8. edition. Praha : Maxdorf, 2009. 1144 pp. Available from <>. ISBN 978-80-7345-166-0.