Mental disorders caused by cannabinoids use
From WikiLectures
Relation to schizophrenia[edit | edit source]
- Changes in the endocannabinoid system may contribute to the pathogenesis of schizophrenia.
- increased activation of the endocannabinoid system through CB1 receptors on GABAergic interneurons in various brain regions -> may lead to hyperdopaminergic and hypoglutaminergic status, which may cause schizophrenia
- Active ingredient and symptoms
- tetrahydroxycanabinol (4-THC)
- Effects: Euphoria, perceptual disturbances, social detachment, impaired judgement,, sociability, lightness, paranoia (i.e. delusions)
- Withdrawal symptoms
- Irritability, agression
- Anxiety
- Depression
- decreased appetite (cannabis increases appetite "munchies")
- insomnia
- somatic symptoms: headache, tremors, abdominal pain, fever, chills, sweating
- Mental complications of cannabis consumption
- Cannabis-induced psychosis (paranoia, delusional thoughts +- hallucinations)
- Cannabis-induced anxiety disorder
- Cannabis-induced sleep disorder
