Kupffer Cells

From WikiLectures

Kupffer Cell

  • specialized stellate macrophages
  • adhere to the sinusoidal endothelium ( in the lumen of the sinusoid), mainly near portal areas (=portal triads)
  • clear the blood of ingested bacterial pathogens that may enter portal blood from the gut
  • remove aged erythrocytes and free heme for re-use
  • act as antigen-presenting cells in adaptive immunity
  • secret cytokines and chemokines that recruit and expand the population of other proinflammatory cells in the liver.