Fibrinogen is a coagulation factor, precursor of fibrin. It is a plasmatic protein that is formed in the liver. Physiological concentration of fibrinogen in plasma is 3–5 g/l. Fibrinogen is also present in α-granules of blood plateles .
Fibrinogen is a symmetrical dimer composed of three pairs of polypeptide non-identical chains, that are bound by disulfide bonds. During hemocoagulation fibrinopeptide A is cleaved by the action of the proteolytic enzyme trombin and fibrin monomer is formed. Then thrombin cleaves fibrinopeptide B and fibrin monomers are polymerized.
During plasma electrophoresis, it ranges between β- and γ-globulins .
Fibrinogen is an acuse phase protein. Plasmatic concentration of fibrinogen rises during the acute response of the organism. Fibrinogen is a risk factor of atherosclerosis. Plasmatic concentration may decrease because of insufficient production (in severe hepatopathies) or increased consumption (DIC).
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- ŠVÍGLEROVÁ, Jitka. Fibrinogen [online]. The last revision 2009-02-18, [cit. 2010-11-13]. <https://web.archive.org/web/20160416225400/http://wiki.lfp-studium.cz/index.php/Fibrinogen>.
- RACEK, J. Klinická biochemie. First edition. Galén – Karolinum, 1999. pp. 65. ISBN 80-7262-023-1.