Equianalgesic doses of opioids

The basic comparative parameter is analgesia induced by 10 mg morphine in s. c. The conversion has an indicative value and numerous inter-individual differences must be taken into account (age, nature and intensity of pain, side effects, sensitivity or tolerance to opioids, method of administration, opioid to which it is rotated). Accordingly, the appropriate dose is still adjusted.

Morphine s. c. (i. m.) 10 20 30 40 50 60 80 100 200
Morphine p. o. 30 60 90 120 150 180 240 300 600
TTS fentanyl v μg / h (Durogesic) 12.5 25 — 50 — 75 100 125 250
TTS fentanyl mg/24 hours 0.3 0.6 — 1.2 — 1.8 2.4 3.0 6.0
Oxycodone p. o. (Oxycontin) 20 (15) 40 (30) 60 (45) 80 (60) 100 (75) 120 (90) 160 (120) 200 (150) 400
Buprenorphine i.m. 0.3 0.6 0.9 1.2 1.5 1.8 2.4 — —
Buprenorphine s. l. in mg / 24 h (Temgesic) 0.4 0.8 1.2 1.6 2.0 2.4 3.2 — —
TDS Buprenorphine v mg / 24 h (Transtec) — 0.84 1.26 1.68 2.1 2.52 3.36 — —
TDS Buprenorphine v μg / h (Transtec) — 35 52.5 70 87.5 105 140 — —
Hydromorphone i. m. (Dilaudid) 1.5 — — — — — — — —
Hydromorphone p. o. (Jurnista, Palladone) 4 8 12 16 20 24 32 — —
Pethidine – meperidine i. m. (Dolsin) 100 (75) — — — — — — — —
Pethidine p. o. 300 — — — — — — — —
Piritramide i. m. (Dipidolor) 15 30 45 — — — — — —
Nalbuphine (Nubain) 20 — — — — — — — —
Tramadol p. o. 150 300 450 600 — — — — —
Tramadol i.m./i.v. 100 200 300 400 — — — — —
Dihydrocodeine p. o. 120 240 320 — — — — — —


Recalculation of doses and calculation of additional doses

MediaWiki:Medical Calculator/Opioids


Source

  • Methodological guidelines for pain pharmacotherapy. In Pain - a journal for the study and treatment of pain. Volume 9, Supplement 3, 2006.