Epileptic Lesion

From WikiLectures

The basic pathological mechanism of epilepsy is the epileptic lesion (focus); it is a differently large population of neurons with pathological electrical activity. In neurons, respectively in their membranes there is an action depolarization (paroxysmal depolarization shift), which causes hyperexcitability and in the lesion there are abnormal discharges, there are also manifestations of hyperautorythmism and hypersynchrony. The lesion may be clinically silent for a long time, and when the seizure threshold is exceeded, a seizure with manifestations of epileptic paroxysm will occur. The nature of the attack itself is always determined by the location of the shock and its spread.

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  • AMBLER, Zdeněk. Základy neurologie. 6. vydání. Praha : Galén-Karolinum, 2006. ISBN 80-246-1258-5.