Drug-induced pulmonary fibrosis

From WikiLectures

Drug-induced pulmonary fibrosis is a development of an intersticial pneumonia and fibrosis due to hypersensitivity or toxic effets of drugs (Template:HVLP, MTX, amiodarone, nitrofurantoin[1], inhalation of O2 in high concentrations):

  • hypersensitivity: ATB (penicilin, ampicilin, nitrofurantoin), some cytostatics (MTX),
  • direct toxicity: cytostatics (bleomycin, cyclofosfamidTemplate:HVLP) → cytostatic lungs.

It can manifest as an acute or chronic condition.[2]

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References[edit | edit source]

  1. GOEMAERE, Natascha NT, Karin GRIJM and Peter Th W VAN HAL, et al. Nitrofurantoin-induced pulmonary fibrosis: a case report. J Med Case Rep [online] . 2008, vol. 2, p. 169, also available from < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408600/?tool=pubmed >. ISSN 1752-1947. 
  2. a b CHILD, P., et al. Internal Medicine. 2nd edition. Prague: Galén, 2007.  ISBN 978-80-7262-496-6 .