Disorders of uric acid metabolism / Questions and case reports
Questions[edit | edit source]
- In humans, carbamoyl phosphate is a precursor of biosynthesis:
- A – uridine monophosphate
- B – Inosine monophosphate
- C – urea
- D – glutamine
- vitamin B12 metabolites play a role in
- A – Catabolism of fatty acids with an odd number of carbon atoms
- B – In the formation of acetyl-CoA from pyruvate
- C – In the transfer of the CH3- group from the tetrahydrofolate coenzyme to homocysteine
- D – In the synthesis of palmitate
- All of the following statements relating to purine nucleotide biosynthesis are correct except:
- A – PRPP is a substrate in this metabolic pathway
- B – Glutamine forms 2 nitrogen atoms of the purine cycle
- C – Formation of N-glycosidic bond only after completion of the base structure
- D – Folate cofactors are involved in the carbons of the purine cycle
- E – Inosine monophosphate is a precursor of both AMP and GMP.
- Gout is caused by an excessive increase in the concentration of uric acid in the blood. The cause can be both overproduction and insufficient excretion. A 15N-labeled amino acid can be administered to recognize this situation. Which is best for this purpose?
Case reports[edit | edit source]
A patient being treated for acute leukaemia[edit | edit source]
A 3-year-old girl is diagnosed with acute lymphocytic leukaemia. She received an infusion, allopurinol, day 2 therapy vincristine, prednisone, methotrexate, etc. In 5 days released home. She continued therapy at home (prednisone, allopurinol. Chemotherapy added again in a month. Then she got soor (candidosis) in her mouth, she couldn't eat.
|S-uric acid||714||547||238||113||137||184 (μmol/l)|
|white blood cells||56 300||3 700||2 800||3 700 (no./ml in blood)|
- How do you explain the high level of uric acid (1st examination performed after 5 days of hospitalization, after discharge)?
- Why was uric acid already normal in future examinations?
- Why was the urea level 0.7 mmol / l?
- What other tests will confirm this finding?
References[edit | edit source]
Related articles[edit | edit source]
Source[edit | edit source]
- MASOPUST, Jaroslav – PRŮŠA, Richard. Patobiochemie metabolických drah. 1. edition. Praha : Univerzita Karlova, 1999. 182 pp. pp. 113- 114. ISBN 80-238-4589-6.