From WikiLectures

Antitussives are drugs that suppress a debilitating, dry and irritating cough.

According to the place of intervention, we divide them into two types:

  • central - reduce the irritability of the cough center
  • peripheral - suppresses stimuli from the tracheobronchial system.

Classification[edit | edit source]

Antitussive codeine type[edit | edit source]

They are characterized by a central mechanism of action. They are more effective than peripheral, but they also have more side effects (possibility of addiction, constipation).


  • codeine − methyl morphine derivative effective, analgesic, combined with sedatives and expectorants
  • ethylmorphine* − stronger analgesic and antitussive effect, higher possibility of addiction,
  • pholcodine* − stronger than codeine, without analgesic effect, less side effects, therefore also suitable for children,
  • dextromethorphan − no analgesic effect, well tolerated, no habit.

Antitussive non-codeine type[edit | edit source]

They are weaker antitussives. They can have a central or peripheral effect. They have no analgesic or euphoric effects. They do not dampen the respiratory center and do not lead to addiction.


  • butamirate − effective, small side effects (anorexia, GIT),
  • dropropizine − comparable to codeine, does not damp the breath center,
  • pentoxyverine*
  • prenoxdiazine*
  • clobutinol*

* = the drug is not currently registered on the Czech market

References[edit | edit source]

  • LINCOVÁ, Dagmar. Základní a aplikovaná farmakologie. 1. edition. GALÉN, 2002. 601 pp. ISBN 80-7262-168-8.

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