Angiotensin

renin-angiotensin system

Angiotensin is an oligopeptide playing a major role in blood pressure regulation . It is part of the so-called renin-angiotensin system. This system represents the stepwise conversion of the angiotensin precursor, angiotensinogen, to the final product of this system, angiotensin II.

Angiotensinogen is a plasma protein (α ₂ -globulin) which is a precursor for the first of the intermediate products of the renin-angiotensin system, angiotensin I. It is produced due to the action of the enzyme of the juxtaglomerular apparatus of the kidneys, renin . Renin cleaves several amino acids (3) from angiotensinogen to form angiotensin I.

Angiotensin I is chemically a decapeptide, which is further converted in the blood, especially in the lungs, by angiotensin-converting enzyme (ACE) to angiotensin II.

Angiotensin II is an active component of the renin-angiotensin system. It has a very strong vasoconstrictive effect on resistance vessels, especially on arterioles, activates the sympathetic system and stimulates the secretion of aldosterone.

Amino acid order:

• Angiotensinogen

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• Angiotensin I

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• Angiotensin II

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Sources

Related Articles

• Juxtaglomerular cells

External Links

• Open Chemistry Database

Použitá literatura

• KITTNAR, Otomar. Lékařská fyziologie. 1. edition. Grada, 2011. 790 pp. ISBN 978-80-247-3068-4.

Recommended Literature

• TROJAN, Stanislav – TROJAN, Stanislav. Lékařská fyziologie. 4. edition. Grada, 2003. 772 pp. ISBN 80-247-0512-5.

• SILBERNAGL, Stefan – DESPOPOULOS, Agamemnon. Atlas fyziologie člověka. 6. edition. Grada, 0000. 0 pp. ISBN 80-247-0630-X.