File:HSC migration from embryonic to fetal hematopoiesis..jpg

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English: Definitive hematopoietic stem cell pools emerge from intra- (AGM) and extra- (yolk sac and placenta) embryonic hematopoietic sites. When the circulation is established and functional, HSCs start their migratory journey and colonize the placenta, followed by the fetal liver that becomes the major hematopoietic organ until the bone marrow colonized by HSCs. The adhesion molecule VE-cadherin expression has been suggested to participate in HSC/progenitor migration but there is no functional data about the molecular mediators of HSC migration in the embryo. The colonization of the fetal liver and the bone marrow are dependent on β1 integrins and the CXCL12/CXCR4 chemokine/receptor axis.
Date Published July 14, 2008.
Source

[1] Direct
StemBook Figure 1 HSC migration from embryonic to fetal hematopoiesis.

  • Magnon, C. and Frenette, P.S., Hematopoietic stem cell trafficking (July 14, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.8.1, http://www.stembook.org.
Author Magnon, C. and Frenette, P.S., Hematopoietic stem cell trafficking (July 14, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.8.1, http://www.stembook.org.
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current21:03, 5 April 2013Thumbnail for version as of 21:03, 5 April 2013600 × 424 (89 KB)wikimediacommons>SmallbotUploading CC-BY images from the the StemBook http://www.stembook.org/ 149/173

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