File:Complement pathway.svg
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Summary
| Description |
English: The complement system is made up of about 25 proteins that work together to “complement” the action of antibodies in destroying bacteria. Complement proteins circulate in the blood in an inactive form. When the first protein in the complement series is activated— typically by antibody that has locked onto an antigen—it sets in motion a domino effect. Each component takes its turn in a precise chain of steps known as the complement cascade. The end product is a cylinder inserted into—and puncturing a hole in—the cell’s wall. With fluids and molecules flowing in and out, the cell swells and bursts.
Deutsch: Das Komplementsystem besteht aus etwa 25 Proteinen, die zusammen die Immunantwort von Antikörpern ergänzen (komplementieren) um so Bakterien zu zerstören. Komplement-Proteine zirkulieren in einer inaktiven Form im Blut. Wenn das erste Protein der Komplement-Kaskade aktiviert wird - typischerweise durch einen Antikörper, der an ein Antigen gebunden hat, kommt es zu einem Domino-Effekt. Jede Komponente aktiviert die nachfolgende in einer Kette von Schritten, die als Komplement-Kaskade bezeichnet wird. Das Endprodukt ist ein Zylinder in der Membran der Zielzelle, der ein Loch in die Zellmembran stanzt. Dies führt zum Austausch von Molekülen und Flüssigkeit zwischen Zellinnerem und Umgebung, die Zelle schwillt an und platzt.
Nederlands: Complementsysteem
Čeština: Komplement sestává z neaktivních proteinů, které se aktivují kaskádovitě třemi známými cestami - alternativní, klasickou a lektinovou. Doplňuje imunitní protilátkovou odpověď proti bakteriím.
Français : Le Système du complément est composé d'environ 25 protéines travaillant ensemble pour "compléter" l'action anti-bactérienne des anticorps. Ces protéines circulent dans le sang sous forme inactive. Lorsque la première de la série est activée, typiquement par un anticorps ayant capté un antigène, les autres s'activent par effet domino : chaque complément prend effet tour à tour en cascade. Le résultat final est un cylindre transperçant la paroi de la cellule. Les fluides et molécules circulent alors librement entre l'intérieur et l'extérieur, faisant gonfler la cellule jusqu'à son explosion. |
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| Date | NIH Publication No. 03–5423, September 2003 (modifications: September 4, 2006) (SVG 1 December 2015) | ||
| Source | Own work based on: http://www.niaid.nih.gov/publications/immune/the_immune_system.pdf | ||
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| Permission (Reusing this file) |
Original work of the US Federal Government - public domain | ||
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Licensing
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This image is a work of the National Institutes of Health, part of the United States Department of Health and Human Services, taken or made as part of an employee's official duties. As a work of the U.S. federal government, the image is in the public domain.
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| This file has been identified as being free of known restrictions under copyright law, including all related and neighboring rights. | ||
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This work has been released into the public domain by its author, Perhelion. This applies worldwide. In some countries this may not be legally possible; if so: |
File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 02:53, 29 September 2020 | | 1,680 × 2,024 (26 KB) | wikimediacommons>Asierog | Spanish translation added, C2a changed for C2b in all languages |
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