Goldmann equation
From WikiLectures
Also the Goldman-Hodgkin-Katz equation
- Allows calculation of membrane potential based on intracellular and extracellular ion concentrations,
- based on Nernst equation,
- takes into account the real permeability of the resting membrane for ions.
![{\displaystyle E={\frac {RT}{F}}\ln {\frac {P_{Na^{+}}[Na_{o}^{+}]+P_{K^{+}}[K_{o}^{+}]+P_{Cl^{-}}[Cl_{i}^{-}]}{P_{Na^{+}}[Na_{i}^{+}]+P_{K^{+}}[K_{i}^{+}]+P_{Cl^{-}}[Cl_{o}^{-}]}},}](https://wikimedia.org/api/rest_v1/media/math/render/svg/3db5f70a0aa33308e768964d91ff1e6fbe8e6bce)
where Px − relative permeability for the given ion.
The result is a resting membrane potential value of -73 mV, as opposed to the Nernst equation, where the result is -90 mV (Nernst equation does not take into account the real permeability of the membrane to ions) .
Links[edit | edit source]
Bibliography[edit | edit source]
- TROJAN, Stanislav, et al. Lékařská fyziologie. 4. vydání. Praha : Grada, 2003. 771 s. ISBN 80-247-0512-5.
References[edit | edit source]
- Vydavatelství VŠCHT. Biochemické pojmy (výkladový slovník) [online]. [cit. 2015-03-19]. <http://147.33.74.135/knihy/uid_es-002_v1/hesla/rovnice_goldmanova.html>.
