File:Steroidogenesis.png

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Summary

Description
English: Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.

White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see Wikipedia:structural formula.

HSD: Hydroxysteroid dehydrogenase

References:

There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.
Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

HSD: Dehydrogenaza hydroksysteroidu
Date
Source Self-made using bkchem and inkscape
Author

David Richfield (User:Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.

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Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Colouring and further organization by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.
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GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.
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28 March 2009

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Date/TimeThumbnailDimensionsUserComment
current17:22, 13 March 2013Thumbnail for version as of 17:22, 13 March 20132,075 × 1,842 (940 KB)wikimediacommons>SlashmeRemoved link from corticosterone to cortisol via CYP17A1, which is incorrect (according to http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )

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