Kidney Transplantation

Kidney transplantation is indicated for any patient with chronic kidney disease. Currently it is considered a routine method of substitution of the renal function that should be preferred over other methods (dialysis, peritoneal dialysis) for prognostic and economical reasons.

Indication
A patient that reaches the 4th stage of chronic kidney disease based on K/D0QI guidelines should be indicated for transplantation as the renal failure progresses. Generally speaking, the sooner – the better. Ideally the patient shouldn't undergo any other method of renal substitution beforehand (hemodialysis).

Diseases leading to kidney failure:


 * 1) glomerulopathy (most often IgA);
 * 2) chronic tubular diseases;
 * 3) diabetic nephropathy;
 * 4) polycystic kidney disease.

In case of a type 1 diabetes diagnosis combined with a severe (terminal) diabetic nephropathy, the kidneys are being transplanted together with the pancreas in the combined pancreas and kidney transplantation, which employs the benefits of the concurrent immunosuppressive therapy that follows. Already undergone kidney transplantation (followed by the immunosuppressive therapy) is a supportive factor for a future pancreas transplantation.

Contraindication

 * Acute or chronic infection;
 * heart failure;
 * coagulopathy;
 * AIDS;
 * malignancy;
 * advanced liver or lung disease.

Donors

 * Living Donors

Most often relatives or partners, but not necessarily. Other people can donate as well. The most important factors are the voluntariness of the donation and health of the donor. In order not to threaten the donor by the removal of a kidney it is necessary to evaluate the future function of the kidney, for example to assess the threat of glomerulonephritis.


 * Dead Donors (Cadavers)

In the Czech republic, the posthumous donation is based on the so-called presumed consent. If a person doesn't proclaim the disagreement with posthumous donation during his or her life, that person is considered for donation automatically. One of the requirements for consideration is the proof of brain death (including panencephalography done twice within 30 minutes). Others are the intact function of the kidney (its preserved peripheral circulation) and cold ischemia for up to 24 hours.

Immunology
The blood type (AB0 system) compatibility is one of the most important. However, the transplantation is possible even with blood type incompatibility (as of 2011 in the Czech republic). Incompatible antibodies must be removed from the recipient's blood by e.g. adsorption or plasmapheresis. In the case of maximum possible HLA complex compatibility and low titer of lymphocytotoxic antibodies the crossmatching yields negative results. By crossmatching we understand the mixing of recipient's serum with donor's lymphocytes and complement. If the crossmatching is positive it is necessary to remove the antibodies.