Thrombocytopenia from reduced platelet production

These are mostly amegakaryocytic thrombocytopenia, which means that there is a reduced amount of megakaryocytes in the bone marrow or megakaryocytes are completely absent. In this case, the attenuation is isolated / more often in the attenuation of the entire myeloid line; Megakaryocytic thrombocytopenia – in the bone marrow a normal / increased number of megakaryocytes with shape deviations
 * More often acquired – treatment with myelotoxic substances + ionizing radiation, viral infections, infiltration of the bone marrow by malignancy, remodeling in myeloproliferative diseases, in idiopathic ones the involvement of immunological mechanisms is assumed.
 * Thrombocytopenia in megaloblastic anemia, PNH , MDS , etc.,
 * Rare hereditary thrombocytopenic thrombocytopathies (eg Bernard-Soulier syndrome).

Diagnostics

 * Bone marrow examination – reduction or absence of megakaryocytes,
 * Severe prognosis (hemorrhage into the CNS),
 * Symptoms from the involvement of other components of hematopoiesis may prevail.

Therapy

 * Secondary thrombocytopenia – treatment of the primary disease process, removal of the causative agent,
 * Immunosuppressive treatment (some cases),
 * Allogeneic bone marrow transplantation ,
 * Symptomatic therapy: glucocorticoids, fibrinolysis inhibitors (PAMBA), platelet transfusion (to ensure surgery).

Related articles

 * Thrombocytopenia
 * Thrombocytopenia of the newborn
 * Hematological examination
 * Pre-transfusion examination
 * Examination of blood coagulation
 * Purpura