Ewing's Sarcoma



Ewing's sarcoma (EWS) belongs to the sarcomas of the Ewing group: EWS, PNET (primitive neuroectodermal tumor), Askin's tumor (Ewing on the chest wall).

It is the 2nd most common malignant bone tumor in children and adolescents, the highest incidence between 5–30 years of age. Early metastasis to the lungs is typical.

It most often develops in the bone marrow of the diaphysis of long bones (mainly femur, tibia). It often mimics acute osteomyelitis: subfebrile, leukocytosis, increased sedimentation, pain, including positive scintigraphy.

Clinical picture: Pain, swelling, pathological fractures

RTG: osteolytic changes with permeative bone destruction + periosteal reaction.

Therapy: 1. neoadjuvant CHT, 2. radical surgical resection, 3. intraoperative / subsequent RT, 4. adjuvant CHT.



Prognosis: 5-year survival 60-76% (in case of no metastases).

Related Articles

 * Osteosarcoma

Literature

 * SOSNA, A., P. VAVŘÍK a M. KRBEC, et al. Základy ortopedie. 1. vydání. Praha : Triton, 2001.  ISBN 80-7254-202-8.
 * DUNGL, P., et al. Ortopedie. 1. vydání. Praha : Grada Publishing, 2005.  ISBN 80-247-0550-8.
 * GALLO, Jiří, et al. Ortopedie pro studenty lékařských a zdravotnických fakult. 1. vydání. Olomouc : Univerzita Palackého v Olomouci, 2011.  ISBN 978-80-244-2486-6.