AMA

Antimitochondrial antibodies (AMA) are a type of autoantibodies usually assessed to diagnose primary biliary choleangitis (PBC), although they are also present in other autoimmune disorders. A number of subtypes of these antibodies have been recognized, some of which are specific mainly for PBC.

List os AMA subtypes and attributed clinical significance

 * Anti-M1 – syphilis;
 * Anti-M2 – primary biliary choleangitis (pathognomic sign);
 * Anti-M3 – drug-induced lupus;
 * Anti-M4 – primary biliary choleangitis (worse prognosis);
 * Anti-M5 – primary and secondary antiphospholipid syndrome, collagenosis;
 * Anti-M6 – drug-induced hepatitis;
 * Anti-M7 – acute myocarditis, cardiomyopathy;
 * Anti-M8 – primary biliary choleangitis (worse prognosis);
 * Anti-M9 – primary biliary choleangitis (usually better prognosis).

Reated articles

 * Autoantibodies