Neomycin

Neomycin is an aminoglycoside antibiotic with very low allergic potential and minimal local irritation. These qualities allow both topical and oral administration of the antibiotic, besides it is not absorbed from the gastrointestinal tract and affects the intestines locally.

Spectrum
Its antimicrobial spectrum includes Gram-negative bacteria (except Pseudomonas aeruginosa) and staphylococci.

Indication
Neomycin sulfate in kombination with bacitracin is called Framykoin, which is used in treatment of the skin infections. It's available as a powder or a salve.

Side effects
Systemic absorption is undesirable, because neomycin has strong nephrotoxic, ototoxic and neurotoxic effects.