Compartment syndrome

Compartment syndrome is a set of symptoms arising from an increase in pressure in a closed anatomical space (compartment), which leads to vascular occlusions causing local ischemia.


 * in this article, compartment is a space defined by the skeleton and the fascial coverings of muscles or intermuscular septa.

Pathophysiology of increased tissue pressure

 * the physiological pressure in the intrafascial space is 3–5 mmHg
 * the perfusion pressure is physiologically approximately 30 mmHg
 * if the intrafascial pressure rises above 30-40 mmHg (in children the limit value is 30 mmHg – lower hypoxic resistance than in adults), compartment syndrome occurs.

In the compartment with increased intrafascial pressure, an increase in venous pressure first occurs. The vein walls have little resistance and collapse, decreasing the arterio-venous pressure gradient. It gradually decreases until the perfusion of the tissue stops and therefore its functions are impaired and eventually necrosis occurs. Due to blood stasis and impaired vascular permeability, fluid moves from the vessels into the interstitium (intrafascial space), where the pressure continues to increase – circulus vitiosus is created.

The length of time the increased pressure must be present for damage to occur varies. Irreversible changes occur during hypoxia:
 * nerves – 2 hours,
 * muscles – 6 hours.,
 * skin – 8–12 hours.

clinical symptoms of compartment syndrome

 * pain in the affected area that worsens with muscle tension, elevation of the limb and does not respond to analgesics,
 * peripheral nerve disorders (gradual development) – paresthesia, dysesthesia or anesthesia in the innervation areas of the nerves that pass through the given intrafascial space,
 * edema of the periphery (fingers), discoloration and limited mobility, later edema of the entire limb,
 * motor function disorder,
 * the last stage is numbness and dysfunction of the entire affected area and the development of general ischemic muscle symptoms, which can lead to systemic symptoms, myoglobinuric renal failure and death.

'''Attention! A preserved pulse on the periphery of the limb does not rule out compartment syndrome!!!'''

Consequences (irreversible changes)

 * 1) sensory and motor disorders,
 * 2) muscle contractures,
 * 3) renal failure,
 * 4) death.

Localization of compartment syndrome

 * 1) limbs – arm, forearm, hand, thigh, lower leg (most common location, 4 compartments), leg,
 * 2) abdomen – increase in intra-abdominal pressure with limitation of diaphragm excursions and venous return,
 * 3) pelvis – oliguria to anuria,
 * 4) chest.

Etiology

 * 1) increased pressure inside the intrafascial space (bleeding, inflammation, burns, venous obstruction, etc.),
 * 2) oppression of the intrafascial space from the outside (tight bandage, incorrect plaster fixation, skin scarring),
 * 3) reduction of the volume of the intrafascial space (closure of the fascial defect, excessive pulling on the limb).


 * active young athletes may develop chronic compartment syndrome (increased muscle volume after exercise and increased hydrostatic pressure in capillaries with movement of intravascular fluid into the interstitium).

Diagnosis of compartment syndrome

 * 1) permanent awareness of the possibility of this serious complication,
 * 2) the presence of a possible etiological factor,
 * 3) clinical signs,
 * 4) auxiliary examinations (oximetry, laboratory – creatine kinase, CRP, D-dimer and others),
 * 5) permanent monitoring of intrafascial pressures - sovereign diagnostic method - piezoelectric sensors, introduced into the relevant intrafascial space.

Differential diagnosis

 * acute arterial occlusions (intrafascial pressure in the norm),
 * arterial injury (arteriography, Doppler),
 * primary nerve injury (disorder immediately after the injury and does not progress),
 * Crush syndrome – long-term muscle compression, when washed out myoglobin clogs the distal tubules of the kidneys,
 * other diseases – osteomyelitis, tendosynovitis, erysipelas, phlegmon (neuromuscular functions normal).

Therapy
Therapy includes measures to reduce tissue pressure before irreversible ischemic changes occur (up to approximately 6 hours):
 * removal of all possible precipitating causes, e.g.loosening plaster fixation of fractures,
 * timely execution of fasciotomy,
 * supportive pharmacotherapy (anti-infectives, anti-edematous treatment, enzyme therapy, vasodilation, analgesics, antiphlogistics, antihistamines).

Fasciotomiy is always indicated if clinical symptoms develop and if there is an increase in pressure above 30-40 mmHg (in children above 30 mmHg). In the case of undeveloped clinical symptoms and pressure values ​​at 20-30 mmHg, a conservative path is chosen with permanent pressure monitoring. If a developing compartment syndrome is suspected during the initial treatment of the fracture, a preventive fasciotomy can be performed.

Abdominal compartment syndrome

 * it is caused by an increase in intra-abdominal pressure above 25 mmHg
 * causes: accidental or spontaneous intra-abdominal bleeding, aortic aneurysm rupture, ascites, acute pankreatitis, intra-abdominal tamponade during surgery, closure of the abdominal wall under tension, etc.
 * clinical symptoms (influence of individual organ systems):
 * respiratory – elevation of the diaphragm, respiratory insufficiency,
 * cardiovascular – increase in central venous pressure, decrease in cardiac output,
 * abdominal – increase in abdominal girth, decrease in blood flow to the splanchnic,
 * renal – oliguria (earliest symptom),


 * intra-abdominal pressure monitoring with a catheter inserted into the bladder (or into the stomach or into the vena cava inf.),
 * treatment decompression laparotomy (indicated by intra-abdominal pressure above 25 mmHg with simultaneous oliguria), immediately after opening the abdominal cavity, an infusion of mannitol with bicarbonate is given (prevention of asystole due to the effect of released acidic metabolites during reperfusion), then temporary closure of the abdominal cavity (Ethizip).

Související články

 * Kompartment syndrom bérce
 * Crush syndrom