Allergic contact dermatitis

Contact allergic dermatitis is a manifestation of type IV hypersensitivity to substances that come into direct contact with the skin (usually haptens).

Etiology and pathogenesis
The development of contact allergic eczema takes place in two phases: sensitizing and elicitation. Due to their size, haptens acquire antigenic properties only after binding to epidermal protein carriers. The antigen is detected and processed by Langerhans cells, which present it to T-lymphocytes. Langerhans cells then migrate to the regional lymph nodes where they change their phenotype. They secrete IL-1, IL-6 and TNF-α , resulting in the proliferation of T-cell clones that have receptors for the specific antigen. T-lymphocytes then migrate to various organs, including the skin (10-20%). The sensitization process spreads throughout the body, with at least 5-7 days required for complete sensitization. The onset of sensitisation is influenced by a number of factors such as the duration and intensity of the action of the allergen, its allergenic properties, the state of immunity and the disposition of the individual. The resulting hypersensitivity is usually permanent.


 * Common sensitising agents:
 * metals (Ni, Co - jewelery, watches);
 * cosmetics ingredients;
 * work environment chemicals;
 * local anesthetics;
 * dyes etc.

After leaving the vessels, the T-lymphocytes can be activated by contact with the appropriate antigen. Macrophages, mast cells and possibly keratinocytes are used in the elicitation phase. Each new contact between the allergen and the sensitized T-lymphocytes triggers the immediate release of cytokines that direct the immune response to remove the allergen from the body as quickly as possible.

If contact eczema is caused by a single substance, it is called monovalent hypersensitivity, more than 1 and less than 5 substances cause oligovalent hypersensitivity, with more causing agents being polyvalent hypersensitivity. Group hypersensitivity refers to a specific part of the primary antigen molecule, resulting in hypersensitivity to a number of chemicals that contain this structure in their molecule. Combined hypersensitivity is caused by the simultaneous or following action of two allergens in one substance.

Clinical picture
The manifestations appear 24-48 h after contact with the causative agent and are limited to the location of contact only. In the acute phase, a highly reddened edematous deposita are formed with rapidly eroding papulovezicles. Oozing on the surface can occur. Rarely we can see formation of bumps. Microscopically spongiosis and intracellular oedema are visible resulting in intraepidermal vesicles. Later crusts form. In the chronic phase, the surface becomes hyperkeratotic and forms ragads or lichenification dominate.

The hematogenous form is caused by a substance to which the patient is sensitized by the bloodstream to the skin, where it causes urticaria. Chronic contact eczema may also spread haematogenously or lymphogenically beyond the primary site of contact.

Diagnostics
In addition to a careful medical history, the basic examination is an epicutaneous test. The principle is the application the test substance under standard conditions and in the correct concentration to healthy skin at a time interval of 2-3 weeks after the skin manifestations are healed. The following is an evaluation and interpretation

Differential diagnosis
It is necessary to distinguish:


 * toxic dermatitis ,
 * atopic eczema ,
 * superficial dermatophytosis ,
 * erysipelas

In chronic manifestations we distinguish


 * psoriasis ,
 * lichen planus ,
 * Paget disease,
 * Bowen disease

Therapy
The basic precondition is to remove the antigen and prevent it from continuing to cause problems. In the acute phase, we apply drying dressing, later solutions of organic dyes, creams, ointments. Using of local corticosteroids are effective, in chronic forms of eczema they are combined with ichtamol or tar preparations. For resistant types, X-ray irradiation with a Bucky lamp can be sometimes effective.

Related articles in czech

 * Dermatitis contacta irritativa
 * Alergeny
 * Léčba alergie
 * Urticaria
 * Erytrodermie