Esophageal Varices

Esophageal varices are venous varices localized in the submucosal layer of esophagus. They are direct consequence of portal hypertension. All the patients with esophageal varices are at the risk of acute bleeding, which can cause be fatal. The most common cause of portal hypertension and esophageal varices is liver cirrhosis. 30–60% of patients with liver cirrhosis are at the risk of esophageal varices bleeding. Rebleeding is very often (60–100% patients with anamnesis of previous variceal bleeding will rebleed in 2 years).

Pathogenesis
Higher blood pressure in portal vein expands in all the veins that carry blood to the portal vein. There are anatomical junctions between venae gastricae (→ portal vein) and venae esophageae (→ superior vena cava) The junctions are called portocaval anastomoses. Because of the higher venous pressure are these junctions more opend and the pressure can expand to esophageal veins too. Esophageal veins are localized in submucosis, over the muscular layer of esophagus. There is scope for the development of varices, which can expand into lumen of esophagus. Their perforation and bleeding is just a question of time.

The esophageal varices bleeding is common in portal pressure higher than 12 mmHg. Normal venous pressure in portal vein is 5–10 mm Hg.

Localization
These varices are usually localized in distal part of esophagus. They can be found in higher level of esophagus or stomach too. The bleeding is most often in gastroesophageal junction.

Patients without acute bleedeng

 * liver cirhosis symptomes;
 * dysphagia;
 * anaemia (microcytes) – sign of previous bleeding;
 * previous hematemesis and/or melena.

Patients with acute bleeding

 * hematemesis (then melena);
 * hypotension;
 * other signs of hemorrhagic shock.

Diagnostic
Gastroscopy is the only diagnostic method, which can prove existance of esophageal varices (visualization) and bring therapeutic solution in the same moment.

Conservative therapy
All the patients with esophageal varices which are not in direct danger of bleeding or patients with portal hypertension without significant varices should be treated for portal hypertension. All the patients with portal hypertension will develop varices (sooner or later…). The therapy of portal hypertension includes:
 * nonselective β-blockers (propranolol, nadolol);
 * TIPS – transjugular intrahepatic porosystemic shunt (which is not conservative therapy of course).

Acute bleeding therapy
Every patient suspected of esophageal varices bleeding should be hospitalized in ICU and treated like every patient with massive blood loss:
 * central and peripheral intravenous catheter;
 * blood loss replacement (but carefully – it can increase portal blood pressure);
 * vasopressin – for vasoconstriction in splanchnical circulation;
 * antibiotic prophylaxis – these patients are at risk of infection.

Acute gastroscopy is necessary! It can be the only solution how to stop bleeding.

The endoscopic treatment methods are:
 * endoscopic variceal ligation (EVL), almost replaced other endoscopic methodes;
 * baloon tamponade (Sengstaken-Blakemore or Minnesota);
 * endoscopic sclerosis of varices.

Other treatment method is acute TIPS or surgical shunt (decompression of portal system).

Related articles

 * Portal Hypertension
 * Gastroscopy