Glycylcycline

Glycylcyclines represent a new group of antibiotics, that is derived from the tetracykline antibiotic minocyklinu. The main agent is tigecycline. Tigecycline is a broad-spectrum ATB (effective against Gram-negative, Gram-positive and anaerobic microbes, but not effective against pseudomonas and proteus). Tigecycline is a chemically 9-t-butylglycylamido derivative of minocycline.

Indications
They are indicated for complicated skin and soft tissue infections as well as intra-abdominal infections.

Mechanism
heir mechanism of action is: inhibition of proteosynthesis, (blokacking protein translation in bacteria by binding tothe 30S ribosomal subunit, blocking the entry of aminoacyl-tRNA molecules into the A site of the ribosome).

Antimikrobial spectrum
It isbroad-spectrum antibiotic,that acts on many clinically important bakteria. Both gram-positive, gram-negative, anaerobic and atypical, including some multidrug-resistant- penicillin rezistant Streptococcus pneumoniae, na Klebsiella pneumoniae and Escherichia coli, Staphylococcus aureus, of gram - negative bacteria shows lower susceptibility to Pseudomonas aeruginosa, Proteus mirabilis, Burkholderia cepacia a Stenotrophomonas malthophilia.

The side effects
The side effects are:
 * nauzea,
 * vomiting,
 * diarrhea.

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