Carbapenems

Carbapenems are highly potent bactericidal beta-lactam antibiotics, stable to beta-lactamases.

Antimicrobial spectrum and indications
Carbapenems have an extremely broad spectrum of action. They are effective against both aerobic and anaerobic microorganisms, G + and G−, including  Pseudomonas aeruginosa  and strains  Streptococcus pneumoniae  highly resistant to penicillins. In general, they have the broadest spectrum of all beta-lactams.

They are used in the treatment of  'life-threatening infections' ,  'nosocomial infections'  caused by multidrug-resistant strains ( Acinetobacter  spp.,  Klebsiella spp. ,  Enterobacter spob. ,  Pseudomonas aeruginosa ), severe pneumonia, complicated intra-abdominal infections and severe skin and soft tissue infections. They are also used in the empirical treatment of febrile neutropenia.

Pharmacokinetics
Carbapenems are administered exclusively parenterally, they penetrate well into tissues and fluids, including cerebrospinal fluid. They are excreted by the kidneys.

Side effects
Less common, insignificant. The most common are allergic skin symptoms and GIT problems. They do not share cross allergy with other beta-lactams. Overgrowth of yeast may occur after therapy.

Carbapenem resistance
Due to its low resistance, carbapenems are among the so-called backup antibiotics, the use of which is limited to the most serious cases with the potential occurrence of resistant strains. Nevertheless, carbapenem-resistant bacterial strains appear. The most important mechanism of carbapenem resistance is the production of carbapenemases. Carbapenemases are enzymes produced by gram-negative microorganisms that are able to hydrolyze a carbapenem molecule. The emergence of carbapenem-resistant strains is associated with the use of broad-spectrum antibiotics. These organisms can cause both asymptomatic colonization and a range of infections such as bacteremia, ventilator pneumonia, urinary tract infections or catheter sepsis. Carbapenemase-producing microorganisms include K. pneumoniae, E. coli, etc. The treatment of infections caused by these microorganisms is very difficult and must involve a combination of carefully selected broad-spectrum antibiotics.

Examples
The combination with cilastatin is used (not ATB, but prevents imipenem from being converted to inactive metabolites in kidneys by dehydropeptidase I activity). Good penetration into body fluids and tissues (lungs, bronchial secretions, bile, cerebrospinal fluids, gynecological tissues, skin, fascia, muscles and peritoneal exudate). It penetrates into G + and G- bacteria.
 * imipenem
 * meropenem, ertapenem

Related Articles

 * Antibiotics
 * Beta-lactam antibiotics
 * Penicillins
 * Monobactams
 * Cephalosporins