Pemphigoid



Pemphigoid has the similar clinical manifestations as pemphigus, but blisters are not determined by the acantholysis and are subepidermal. The prognosis is more favorable, treatment – corticosteroids and immunosupressive drugs.

Bullous pemphigoid
Parapemphigus or senile pemphigus is an autoimmune disease. Most offenly occurs in older people (70–80 years old). A reliable differentiation from the pemphigus is possible only with histological methods. Blisters on slightly inflamed base, on limbs, later on torso, symmetrical; leave pigmentation. Nikolsky's sign is negative. The course of the disease is prolonged, a spontaneous remission may also occur. Sometimes it occurs as paraneoplasia or after a drug treatment (penicillin, furosemide, Brufen…).

Benign mucosal pemphigoid
For scarring pemphigus is typical the production of the IgG and IgA against BM with C3 deposits. It affects conjunctiva, nasal cavity, pharynx, larynx, nose, genitals, anus. Heals with a scar, if it affects the eyes it can cause blindness, leaves the stenosis. Occurs rather in older individuals.

Related articles

 * Ocular cicatricial pemphigoid
 * Pemphigus