Lysosome-related organelles


 * LROs stands for lysosome-related organelles, which are lysosome-like organelles that have membrane parameters of lysosomes and some of their enzymes, but only residual or zero degradation activity (unlike lysosomes).


 * These organelles include:
 * Azurophilic granules of eosinophilic and neutrophilic granulocytes, the disorders of which lead, among other things, to intestinal diseases.
 * Melanosomes of melanocytes whose deficiency leads to a specific type of albinism.
 * Delta granules of platelets, the disorder of which leads to increased bleeding.
 * Lytic granule of NK cells and Tc lymphocytes, the disorder of which leads to immunodeficiency.
 * Secondary granules of pneumocytes II, whose disorder leads to pulmonary fibrosis.
 * Osteoclast lysosomes


 * Syndromes with LRO include Chediak-Higashi syndrome and Hermansky-Pudlak syndrome.