Incretins

Incretins are hormones produced in the gut. These include glucagon-like peptide 1 (GLP 1) and glucose-dependent insulinotropic polypeptide (also gastric inhibitory polypeptide, gastric inhibitor polypeptide; GIP). Their production is stimulated by food intake. They were first isolated from the saliva of a poison ivy lizard.

Among other things, incretins increase the sensitivity of pancreatic β-cells to secretory stimuli and decrease glucagon secretion, thereby reducing hepatocyte glucose output. Therefore, dipeptidyl peptidase 4Template: HVLP (DPP-4) inhibitors and GLP-1 agonists are used to treat type 2 diabetes mellitus - Template: HVLP, Template: HVLP and others = incretin analogs.

Resources

 * Oral antidiabetics
 * Diabetes mellitus - type 2
 * Incretin analogues