Oxazolidinones

Oxazolidinones are a group of antibiotics with a "bacteriostatic" effect that inhibit proteosynthesis.

Indication
They are among the  backup  antibiotics. Suitable for  'nosocomial infections] infections, pneumonia.

Contraindications
We do not give children (little experience), careful administration in hypertension, bipolar disorder.

Mechanism of action
The mechanism of action is binding to the 50S ribosomal subunit. Inhibits the formation of the initiation complex.

Antimicrobial spectrum
Antibiotics act on '' 'G +' 'bacteria. They are also effective against MRSA, GISA, VRE, enterococci,  Clostridium difficile  and  Mycobacterium tuberculosis .

Side effects
Side effects are associated with GIT (diarrhea, nausea, vomiting). Hematotoxicity - after 2-4 weeks, allergic skin reactions, headache, MAO inhibition.

Pharmacokinetics
Absorption is excellent, penetrates well into tissues and secretions, penetrates the CNS relatively well, is completely biotransformed in the "liver", eliminates inactive metabolites in the urine. The application is possible  'parenterally'  and  'orally' .

Drug interactions
Numerous drug interactions. Mainly with  'vasoactive'  amines, serotinergic drugs. It potentiates their effect. It is necessary to avoid foods rich in  tyramines' .

Representatives
  '': Zyvoxid, Dilizolen, Gramposimide. Linezolid dosage 2 × 600 mg / d i.v. or p.o.

Related Articles

 * Antibiotic for the treatment of staphylococcal infection
 * Tetracycline antibiotics
 * Antibiotic resistance

Source

 * ws:Oxazolidinony