Protein C

Thrombomodulin:

Protein C is a substance with an anticoagulant effect. Its inactive form is formed in the liver (formation is dependent on vitamin K), activation of protein C takes place using thrombin bound to endothelial thrombomodulin. Active protein C forms a complex with protein S, which acts as its cofactor. In this complex, protein C has the ability to proteolytically inactivate (cleave) activated coagulation factors V and VIII.

Links

 * Hemocoagulation
 * Hemocoagulation versus anticoagulation