Krukenberg's Tumor

__BEZOBSAHU__ náhled|Krukenbergův tumor

Krukenberg's tumor is a secondary malignant tumor of the ovaries, which most frequently metastases from he GIT, or less frequently from the breast, lung or contralateral ovary. In 80% of the cases, it is found bilaterally. It is a rarer target for metastatic GIT tumors in Europe, but in Japan, for example, it is one of the most common sites.

Morphology
Tumors are well differentiated mucinous cells, called signet ring cells -  due to the imposition of mucinous vacuoles that pushes the core to the periphery. Mucoid degeneration is also often present. The presence of both differentiated mucinous cells and signet ring cells indicates a GIT origin (most often gastric adenocarcinoma, followed by colorectal cancer)

Clinical Manifestation

 * Abdominal pain;
 * Irregular menstrual bleeding;
 * Pain during pelvic intercourse.

Treatment and Prognosis
Differentiation from the primary ovarian tumor is requires for determination. Usually, the surgical solution is supplemented with chemotherapy.

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