Deubiquitination

In the eukaryotic cell, in addition to ubiquitination of proteins, their deubiquitination also occurs. The enzymes responsible for this process are called deubiquitinases and denoted by the abbreviation DUB. We can divide them into the following five groups:
 * 1) ubiquitin C-terminal hydrolases,
 * 2) ubiquitin specific proteases,
 * 3) proteases with the Machado-Joseph disease domain,
 * 4) proteases from ovarian tumors,
 * 5) proteases with a JAMM domain.

Today, 75 DUBs are known, which interact with hundreds of proteins and play an immense number of different roles in the eukaryotic cell. Note that one of the JAMM domain deubiquitinases, referred to in human cells as Poh1, is part of the eukaryotic proteasome and plays a key role in its proper functioning.

Related articles

 * Proteins
 * Degradation of proteins
 * Ubiquitination
 * History of ubiquitin-proteasome system
 * Proteasome
 * Proteasome inhibitors
 * Translation

Source

 * CVEK, Boris. From ubiquitin to antabuse. Britské listy: a newspaper about everything that is not talked about much in the Czech Republic [online]. 2011, year. -, pp. -, also available from < https://blisty.cz//legacy.blisty.cz/art/56680.html >. ISSN 1213-1792.

Reference

 * 1) KOMANDER, David, Michael J CLAGUE a Sylvie URBÉ. Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol [online]. 2009, vol. 10, no. 8, s. 550-63, dostupné také z . ISSN 1471-0072 (print), 1471-0080.
 * 2) SOWA, Mathew E, Eric J BENNETT a Steven P GYGI, et al. Defining the human deubiquitinating enzyme interaction landscape. Cell [online]. 2009, vol. 138, no. 2, s. 389-403, dostupné také z . ISSN 0092-8674 (print), 1097-4172.