Ion converters

They are insoluble macromolecular resites that bind bile acids (cholesterol metabolites) in the intestinal luminum and prevent their reabsorption.

Normally, about 95% of the excreted bile acids get back into the liver (enterohepatic circulation).

Decreased return after administration of ion exchangers leads to increased synthesis of bile acids from cholesterol. This is manifested by increased uptake of LDL by the liver and the mobilization of cholesterol from tissues.

Side effects

 * Constipation, bloating (it is therefore advisable to supplement the diet with foods rich in fiber)
 * rarely malabsorption of vitamin K,
 * dry peeling skin
 * the absorption of certain medicines (cardiothoracic drugs, tiazide diuretics, warfarin, some NSAIDs may be impaired – it is advisable to administer this drug at least an hour before the application of the ion converter).

Shortcuts

 * Cholestyramine.
 * Colestipol.

Related articles

 * Hypolipidemics
 * Lipoproteins

Source


Cathegory:Patophysiology Cathegory:Cardiology Cathegory:Pharmacology Cathegory:Internal medicine