Eicosanoids/Questions and case reports

Questions

 * 1) What is the difference in the effect of aspirin and nonsteroidal anti-inflammatory drugs of the indomethacin type on cyclooxygenase activity?
 * 2) 'Some asthmatics experience an exacerbation of their symptoms when they take non-steroidal anti-inflammatory drugs. How can this be explained from a biochemical point of view?
 * 3) Which pair has the opposite effect?
 * 4) * A – cholic and lithocholic acid
 * 5) * B – 5-HPETE and leukotriene D4
 * 6) * C – Lactosylceramide and galactocerebroside
 * 7) * D – Thromboxane A2 and prostacyclin (PGI2)
 * 8) * E – Acetone and 3-hydroxybutyrate

Patient with asthma
A woman, 46 years old, was treated on an outpatient basis for asthmoid bronchitis by triamcinolone acetonide inhalation. Before being admitted to the hospital, she had an upper respiratory tract infection, and her breathing difficulties significantly worsened, turning into an acute asthma attack with significant bronchospasm. glucocorticoids i.v.

Questions:
 * 1) What is the mechanism of action of glucocorticoids in the treatment of asthma?

Cardiovascular disease patient
A man with ischemic heart disease takes small doses of aspirin as a preventative measure.

Questions:
 * 1) What is the pathobiochemical mechanism of the beneficial effect of aspirin on the occurrence of acute myocardial infarction?
 * 2) What adverse effect can the administration of acetylsalicylic acid have in some patients?

Related Articles

 * Prostaglandins
 * Prostaglandin E1
 * Thromboxane A2
 * Nonsteroidal antiphlogistics

Source


[[Category: Pathophysiol