Drug-induced pulmonary fibrosis

Drug-induced pulmonary fibrosis is a development of an intersticial pneumonia and fibrosis due to hypersensitivity or toxic effets of drugs (, MTX, amiodarone, nitrofurantoin, inhalation of O2 in high concentrations):
 * hypersensitivity: ATB (penicilin, ampicilin, nitrofurantoin), some cytostatics (MTX),
 * direct toxicity: cytostatics (bleomycin, cyclofosfamid) → cytostatic lungs.

It can manifest as an acute or chronic condition.

Klinický obraz

 * Dyspnoea,
 * Dry, irritating cough,
 * X-ray: localized / diffuse interstitial damage, late honeycomb lung.

Therapy

 * Discontinuation of the drug, glucocorticoids.

Související články

 * Intersticiální plicní procesy
 * Postradiační fibróza plic