Metabolic osteopathies

Metabolic osteopathies are diseases caused by imbalances between bone formation and resorption and disorders in bone mineralization → osteopenia and bone loss (osteoporosis, osteomalacia) or sclerotization of the bone and increase in bone mass (Paget's disease, osteopetrosis). These osteopathies are caused by dysfunction of bone cells, gene abnormalities (defects in collagen I synthesis, etc.), increased expression of bone morphogenetic proteins, renal dysfunction, endocrinopathies, tumor secretion of substances affecting bone metabolism.