Isoprenaline

Isoprenaline is a non-selective β-receptor agonist with effects similar to adrenaline.

Effects
Side effects result from the mechanism of action – an increase in heart rate with a decrease in the availability of oxygen to the myocardium, a proarrhythmogenic effect.
 * stimulation of β1-adrenergic and β2-adrenergic receptors
 * increase in strength of myocardial contraction (positive inotropic effect)
 * significant increase in heart rate
 * vasodilatation in the pulmonary vascular bed without affecting the flow through the renal and mesenteric vascular bed

Indication

 * during circulatory collapse (shock) with a decrease in cardiac output and an increase in central venous pressure
 * prevention of brochospasm and pulmonary hypertension during anesthesia
 * in the treatment of permanent bradycardia, conduction disorders - AV blockade, until the introduction of cardiac stimulation
 * therapy Adams-Stokes syndrome

Contraindications

 * sinus tachycardia higher than 130/min
 * atrial and ventricular hyperexcitation
 * digitalis intoxication
 * acute coronary insufficiency, acute myocardial infarction - except in the case of simultaneous AV block with extreme bradycardia
 * simultaneous administration with adrenaline is contraindicated

Related Articles

 * Sympathomimetics
 * Adrenaline