Nelson syndrome

A relatively rare pituitary adenoma that occurs in patients after adrenal removal, which is increasingly producing ACTH. As a result of adrenalectomy, feedback inhibition of CRH by cortisol is lost, thus increasing hypothalamic CRH secretion and thus ACTH overproduction.

The first symptoms may include visual field loss and hyperpigmentation.

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 * Hypothalamic-pituitary system