Antidepressant intoxication

== Antidepressants ==
 * Frequent intoxication, these are substances that inhibit the reuptake of catecholamines and serotonin in the synapse, significant anticholinergic effects,
 * representatives of TCAs (tricyclic antidepressants) – imipramine' (Melipramine&reg;), amitryptiline', dosulepin' (Prothiaden&reg;),
 * have cardiotoxic manifestations - already at 10 times the therapeutic dose!

Clinical picture

 * Poisoning TCA will cause an anticholinergic syndrome - dryness of the mucous membranes, mydriasis, tachycardia, slowing of the GIT, retention of urinee,
 * impaired consciousness, convulsions,
 * EKG – prolongation of the nitroventricular conduction (QRS widening), dysrhythmia (danger of ventricular fibrillation).

Therapy

 * The antidote is not
 * basis of treatment – high doses of activated charcoal, care of vital functions, symptomatic therapy.

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 * Antidepressants