Portal Hypertension

The venous blood pressure 10 mmHg and higher in portal vein is classified as portal hypertension (normal pressure in vena portae is 5-10 mmHg). The portal hypertension is one of the most important liver cirhosis complications. Is presented in more than 60% of patients with liver cirhosis. Its consequences are esophageal varices and splenomegaly.

Pathophysiology
The vascular ressistance in normal healthy liver (in liver sinusoids) is minimal. Then the normal pressure in portal vein is high enough to hold liver functional circulation. If the vascular ressistance gets higher, the pressure in portal vein must go higher to keep the circulation. Reasons of higher vascular ressistance can be:
 * presinusoidal – typically portal vein trombosis;
 * sinusoidal – liver parenchym diseases, especially liver cirhosis, liver fibrosis (Wilsons disease, hemochromatosis);
 * postsinusoidal – hepatic veins trombosis (Budd-Chiari syndrome) or inferior vena cava trombosis.

The sinusoidal ressistance is the most often.

Splenomegaly
Splenomegaly in PH is caused by higher blood pressure in lienal vein. If the progress of PH is rapid, it can even cause intraabdominal bleeding (rupture of spleen), but it is quite infrequent.

Esophageal varices
There are junctions between portal vein and superior vena cava (portocaval anastomoses between gastric veins and esophageal veins). The esophageal veins are localized in esophageal submucosis. If the high blood pressure in portal vein expands here (the vascular ressistance is lower than in liver), the consequence are esophageal varices, which are dangerous because of possible bleeding. Esophageal varices bleeding is quite often complication in patients with liver cirhosis (30-60% of them).

Blood congestion in gut
Blood congestion in portal vein expands to vena lienalis and intestinal veins (via mesenterical vein). The consequence is mucosal hyperemia of small intestine, which can cause malabsorption.

Hypercirculation
Hypercirculation is caused by opened portocaval anastomoses. The vascular ressistance here is lower than the vascular resistance in liver. It causes, that these junctions are not only opend, but even the blood flow here can be pretty high. The portal blood (with substances obtained in small intestine) can "flow round the liver" to superior or inferior vena cava. The blood circulation is more rapid than it should be (it is hypercirculation).

Hepatic encephalopathy
Hepatic encephalopathy is multifactorial neuropsychiatric syndrome. It is probably caused by decreased liver metabolism (cirhosis...) and hypercirculation (a part of the portal blood flows round the liver via portocaval anastomoses). Then the blood in system circulation contains higher level of toxins (from gut) and ammonia (produced by bacteries in gut). This encephalopathy is characterized by disturbances in consciousness and behavior, personality changes and neurological symptomatology (flapping tremor).

Diagnostic

 * physical examination: caput medusae - dilated subcutaneous veins of abdomen, palmar erythema,
 * USG: splenomegalia, hepatic venous pressure gradient (HVPG, normal is 3-4 mmHg), ascites
 * gastroscopy: esophageal varices and their bleeding
 * lab: elevated liver markers (ALT, AST), koagulopathy (INR > 1,5), decrease of albumin
 * hematology: decrease in platelets (because of splenomegaly)

Therapy
Therapy includes therapy of PH itself and therapy of complication (esophageal varices and its bleeding, encephalopaty, ascites...), therapy of liver cirhosis, liver transplantation.

Pharmacotherapy
Nonselective β-blockers with ISA like propranolol or nadolol - effects: Optimal heart rate decrease is -25% of heart rate or heart rate 55/min.
 * 1) vasoconstriction in splanchnic arterial circulation;
 * 2) vasoconstriction in portal venous system;
 * 3) decrease of cardiac output.

TIPS
Transjugular intrahepatic porosystemic shunt is arteficial junction between portal vein and inferior vena cava. This shunt is introduced via vena jugularis interna. This methode should be used in patients with complicated pharmacoresistant portal hypertension (often esophageal varices bleeding). . This percutaneous methode replaced surgical shunt.

Related articles

 * Esophageal varices