Bowen's disease

Bowen's disease (Morbus Bowen, Bowen's dermatosis) is an in situ intraepithelial carcinoma that often progresses to squamous cell carcinoma.

Etiology and clinical manifestation
It most often occurs on the trunk and lower limbs in middle-aged and older people. The etiology is multifactorial (UV radiation, chemicals, HPV infections).

Clinically, it appears to be a slowly progressing, sharply demarcated, slightly elevated deposit, round in shape, brown to brownish-red in color, growing to a size of 10 cm. The surface is usually covered with scabs or scales. It is usually accompanied by itching and does not show a tendency to heal. After removing the surface, a wetting base is visible.

The analogy in the genital area is Queyrat's erythroplasia.

Diagnosis and therapy
We diagnose it histopathologically - epidermis with acanthosis and a tendency to dyskeratosis, detection of atypical cells and mitoses.

Therapy consists of radical removal of the lesion (surgical, cryotherapy, laser ablation).

Virtual preparations
https://www.pathowiki.org/pathowiki/index.php/Morbus_Bowen