Liver involvement in infectious diseases

EBV

 * hepatomegaly, liver tests are routine
 * often occurs in pneumococcal pneumonia and enterovirus diseases, parainfectious liver disease
 * mild elevation of ALT is also in erythema migrans in Lyme disease

HSV, VZV

 * they can damage the liver, especially in people with reduced immunity

CMV

 * the source of the infection are sick patients or carriers – they excrete the virus in saliva and urine
 * it spreads horizontally (by air, contact, breast milk, transfusion), and persists vertically in the body
 * acquired CMVosis occurs asymptomatically or as mild influenza in immunocompetent individuals, rarely as heart attack
 * hepatitis occurs after transfusion or in immunocompromised individuals
 * congenital CMVosis due to infected mother and/or infected milk
 * either miscarriage or congenital disorders of the CNS, heart, or eyes

Diagnosis

 * virus isolation, serology

Therapy

 * ganciclovir (antiviral)