Langerhans cells

They are huge multinucleated elements found in granulomas. They are characterized by their extensive cytoplasm and several tens to hundreds of nuclei arranged in the shape of a wreath around the entire perimeter of the cell or in the shape of a horseshoe. They are often part of immune granulomas in specific inflammations sarcoidosis and TB.

Their formation by the fusion of epithelioid macrophages is induced by the secretion of IFN-γ by CD4+ T lymphocytes.