Howell-Jolly bodies

Howell-Jolly bodies are basophilic bodies in erythrocytes, their basis is DNA residues. Normally they occur only occasionally, their presence is a sign of damage to the Spleen. They appear in the following conditions:
 * state after splenectomy,
 * spleen trauma,
 * damage to the spleen in sickle cell disease,
 * trophy of the spleen, which sometimes accompanies celiac disease,
 * damage to the spleen during radiotherapy,
 * hemolytic anemia,
 * megaloblastic anemia,
 * myelodysplastic syndrome,
 * hereditary spherocytosis.