Glycylcyclins

Glycylcyclines represent a new group of antibiotics that is derived from the tetracycline antibiotic minocycline. The main representative is tigecycline'. Tigecycline is a broad-spectrum ATB (effective against Gram-negative, Gram-positive and anaerobic microbes, but not effective against pseudomonads and proteums). Tigecycline is chemically a 9-t-butylglycylamido derivative of minocycline.

Indication
They are indicated for complicated skin and soft tissue infections as well as intra-abdominal infections.

Mechanism of action
Their mechanism of action is: inhibition of proteosynthesis, (blocking of translation of protein in bacteria by binding to the ribosomal subunit 30S', blocks the entry of aminoacyl-tRNA molecules into the A site of the ribosome ).

Antimicrobial spectrum
It is a broad-spectrum antibiotic' that acts on many clinically important bacteria. Both gram-positive, gram-negative, anaerobic and atypical, including some multi-resistant, penicillin resistant Streptococcus pneumoniae, Klebsiella pneumoniae and Escherichia coli , Staphylococcus aureus, from gram-negative bacteria shows a lower sensitivity to Pseudomonas aeruginosa, Proteus mirabilis, Burkholderia cepacia and  Stenotrophomonas malthophilia.

Side effects
Side effects are:
 * nausea,
 * vomiting,
 * diarrhea.

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