Parasympathomimetics

General properties
Parasympathomimetics mimic the effects that arise from irritation of the parasympathetic system. They are substances that act on three types of muscarinic receptors (M-receptors). Their effect is similar to acetylcholine. We can therefore also call them synergists of acetylcholine on M receptors. Most parasympathomimetics are non-selective substances that can be used in the therapy of certain diseases.

Types of parasympathomimetics
Parasympathomimetics can be divided into two large groups:


 * 1) Direct parasympathomimetics – directly acting, stimulate M receptors
 * 2) Indirect parasympathomimetics - acting indirectly, they block ACHE (acetylcholinesterase) and thereby increase the amount of neurotransmitter (ACH).

Effects
PSMs have the most pronounced effects in the area of ​​smooth muscle. They are used to increase the tone and motility of the GIT. Indirectly acting PSMs improve the condition in myasthenia gravis.

Adverse effects
Adverse effects such as diarrhea, vomiting , nausea , stomach cramps, sweating, miosis, increased salivation may occur.

Contraindications
Do not use in case of obstruction of the urinary tract.

Related articles

 * Indirect parasympathomimetics