Deubiquitination

In the eukaryotic cell, in addition to ubiquitination of proteins, their deubiquitination also occurs. The enzymes responsible for this process are called deubiquitinases and denoted by the abbreviation DUB. We can divide them into the following five groups:
 * 1) ubiquitin C-terminal hydrolases,
 * 2) ubiquitin specific proteases,
 * 3) proteases with the Machado-Joseph disease domain,
 * 4) proteases from ovarian tumors,
 * 5) proteases with a JAMM domain.

Today, 75 DUBs are known, which interact with hundreds of proteins and play an immense number of different roles in the eukaryotic cell. Note that one of the JAMM domain deubiquitinases, referred to in human cells as Poh1, is part of the eukaryotic proteasome and plays a key role in its proper functioning.

Related articles

 * Proteins
 * Degradation of proteins
 * Ubiquitination
 * History of ubiquitin-proteasome system
 * Proteasome
 * Proteasome inhibitors
 * Translation