Mental disorders caused by opioids use

Why are they taking it?

 * used for their euphoric effect
 * high addiction rate

Route of administration:

 * IV or inhaled or snorted

Mechanism of Action:

 * kappa, delta and mu-receptor agonists


 * Opioid induced disorder → depressive disorder, anxiety disorder, sleep disorder, sexual dysfunction, delirium

Therapy:

 * longer-acting opioid e.g. methadone, buprenorphine


 * many internal comorbidities: malnutrition, infections (HIV, HCV), endocarditis, sepsis