Portal:Biology and Genetics

-

Monogenic inheritance

 * Gene
 * alleles
 * allelic interactions
 * genotype
 * phenotype
 * polymorphism
 * structural gene
 * genes for tRNA, rRNA


 * Chromosome
 * autosomes
 * sex chromosomes
 * chromosome X
 * chromosome Y
 * mitochondrial DNA


 * Mendelian pattern of inheritance
 * Mendel's experiments
 * monohybridism
 * dihybridism (free assortmnent of alleles, linkage)
 * parental, F1, F2, F3 generations
 * backckross
 * non-allelic gene interactions


 * Non-Mendelian Inheritance
 * mitochondrial inheritance
 * imprinting


 * Use of Mendelian Genetics Laws in Human Genetics
 * Clinical genetics
 * Genealogy studies
 * Monogenic disorders (blood groups, transplantation antigens, repetitive sequences, restriction fragment length polymorphism)
 * Autosomal dominant inheritance (AD), examples
 * Autosomal recessive inheritance (AR), examples
 * X-linked dominant inheritance (GD), examples
 * X-linked recessive inheritance (GR), examples

Metaphasic Chromosome

 * Structure of metaphasic chromosome
 * Types of metaphasic chromosomes
 * Human karyotype

Chromosome Assessment

 * Material
 * Chromosome identification

Chromosomal Aberrations

 * Structural chromosomal aberrations
 * Numerical chromosomal aberrations
 * Acquired chromosomal aberrations
 * Tumor cytogenetics
 * Prenatal screening

Cell Cycle

 * Cell cycle phases
 * Cell cycle regulation
 * Cell cycle disturbances

Molecular Genetics

 * DNA - structure, replication
 * RNA - structure, transcription
 * Proteins - structure, translation
 * "non-coding" RNA
 * Posttranscriptional a posttranslational editing

Oncogenetics

 * Biological aspects of tumorigenesis
 * (Proto)oncogenes
 * Tumor-supresor genes
 * Mutator genes

Ecogenetics

 * Gene-environment interaction
 * Pharmacogenetics
 * Toxicogenetics
 * Nutrigenetics

Genetics of Complex Traits

 * Genetic analysis of complex traits
 * Linkage studies
 * Association studies
 * Genetics of common metabolic diseases
 * Genetics of neurodegenerative diseases
 * Genetics of addiction
 * Genetics of infectious diseases

Evolution Genetics

 * Mutation
 * Natural selection
 * Genetic drift
 * Gene flow
 * DNA sequence evolution
 * Gene evolution
 * Evolution of ontogenesis

Methods of proteomics

 * Preanalytical sample preparation
 * 2-D electrophoresis
 * Liquid chromoatography
 * Isoelectric focusation
 * Mass spectrometry
 * Protein arrays

Epigenetics

 * DNA methylation
 * Imprinting
 * X-chromosome inactivation
 * Histone code
 * Epigenetics and human disease

Models in Medical Genetics and Genetic Research

 * in vivo, ex vivo'' - model organisms
 * unicellular models
 * Arabidopsis thaliana
 * Caenorhabditis elegans
 * Drosophila melanogaster
 * Danio rerio
 * Rattus norvegicus
 * Mus musculus
 * Pan troglodytes
 * in vitro - cell and tissue culture
 * in silico - computational models

Gene therapy

 * Vectors