Surgical treatment of malignant gynecological tumors

Surgical treatment of malignant gynecological tumors  is an effort to surgically remove the tumor itself, its metastases, micrometastases and biopsy material for staging examination. It varies according to the type of tumor, the clinical stage of the tumor and according to the woman's wish to preserve the possibility of pregnancy (fertility-preserving procedures).

Cervical carcinoma
The most important thing here is that the treatment is diametrically different at various clinical stages. Surgical treatment is dominant in the early stages and is curative in intent; in the later stages, non-surgical treatment prevails, surgical only in palliative indications. About 40% of women are under the age of 40 so we have to take into account a possibility of fertility-preserving procedures. In this case, the procedure is performed less radically and thus with a higher risk of disease relapse but leaves the woman with the possibility of pregnancy.

Stage IA
If the tumor is smaller than 5 mm (stage IA), the basic treatment is a simple hysterectomy. It is possible to extend it by bilateral adnexectomy but it is not necessary (at the age of over 45 it is more likely to be performed, at the age of 40 rather not). Conization is performed as a fertility-preserving performance.

Stage IB
If the tumor is larger than 5 mm but still located only in the cervix (stage IB), Wertheim's radical hysterectomy with pelvic lymphadenectomy is performed. The radicality of hysterectomy consists in the removal of the parametrium and part of the vagina along with the uterus. Again, a bilateral adnexectomy may or may not be included. The point of pelvic lymphadenectomy is a staging examination. It begins with the search for the sentinel node which is histologically examined in the most detail and then with the extirpation of the other macroscopically visible pelvic nodes. The fertility-preserving procedure is conization, if the entire tumor is involved, or trachelectomy, i.e. removal of most of the cervix. Trachelectomy can be performed if the tumor does not extend closer than 1 cm from the uterine isthmus. This one centimeter is important for maintaining fertility. It is possible to increase the radicality of trachelectomy (radical trachelectomy) by removing the parametrium and by the vaginal cuff.

Stage IIB
If the tumor extends beyond the cervix (stage IIB), radiotherapy (teleradiotherapy in combination with brachyradiotherapy) is primarily indicated. Surgical treatment can be indicated palliatively and to specify the extent of radiotherapy. Laparoscopic operations are performed with pelvic lymphadenectomy to remove metastases and para-aortic lymphadenectomy to determine the extent of radiotherapy.

Endometrial carcinoma
If the tumor extends only to the endometrium, a simple hysterectomy with bilateral adnexectomy is performed (frequent metastases in the tube and ovaries). If the tumor extends into the myometrium, the benefit of radical hysterectomy may be considered. For high-risk cancers (stage IB and higher, grade 3 or 4, serous, clear cell or undifferentiated type), pelvic and para-aortic lymphadenectomy is indicate. However, this is an extensive procedure that is not often performed due to the advanced age of patients with endometrial cancer.

Ovarian cancer
There are three stages: borderline tumor of ovary (BTO), early ovarian cancer (EOC) and advanced ovarian cancer (AOC). Surgical treatment is the essential modality for all stages. 80% of ovarian cancers are diagnosed at the AOC stage.

Borderline tumor of ovary
A simple hysterectomy with bilateral adnexectomy is indicated for BTO. As a fertility-saving treatment it is possible to perform a unilateral adnexectomy or even only resection of the tumor (if the woman has only one ovary affected by the tumor). Chemotherapy is not indicated.

Early ovarian cancer
With curative intent is performed hysterectomy, bilateral adnexectomy, omentectomy, appendectomy, pelvic lymphadenectomy and para-aortic lymphadenectomy. A fertility-preserving procedure can only be performed for stage IA Grade 1 and not for a clear cell or undifferentiated carcinoma; unilateral adnexectomy, omentectomy, pelvic and para-aortic lymphadenectomy are performed. However, if the histological examination is positive, it is necessary to complete the operation in the original manner.

Advanced ovarian cancer
The purpose of surgical treatment is in this case palliative. Median survival is 2 years; ovarian cancer mainly spreads by implantation and lymph. Therefore, the median survival rate doubles upon reaching zero macroscopic residue (stage R0). The surgery is performed on the same scale as for EOC, supplemented with macroscopic debulging of metastases, most often peritonectomy, rectal amputation, mesentery resection, resection of the ileocecal region, sometimes also liver resection, diaphragm stripping and splenectomy.

Související články

 * Abdominální gynekologické operace
 * Operace zevních rodidel
 * Vaginální gynekologické operace
 * Zhoubné nádory v gynekologii
 * Nechirurgická léčba zhoubných gynekologických nádorů
 * Zhoubné nádory vulvy a pochvy
 * Zhoubné nádory děložního hrdla
 * Zhoubné nádory děložního těla
 * Ovariální nádory

Externí odkazy

 * www.onkogyn.cz (např. aktuální TNM klasifikace, jde o stránky Onkogynekologického centra VFN)