Disorders of uric acid metabolism / Questions and case reports

Questions

 * 1) In humans, carbamoyl phosphate is a precursor of biosynthesis:
 * 2) * A – uridine monophosphate
 * 3) * B – Inosine monophosphate
 * 4) * C – urea
 * 5) * D – glutamine
 * 6) vitamin B12 metabolites play a role in
 * 7) * A – Catabolism of fatty acids with an odd number of carbon atoms
 * 8) * B – In the formation of acetyl-CoA from pyruvate
 * 9) * C – In the transfer of the CH3- group from the tetrahydrofolate coenzyme to homocysteine
 * 10) * D – In the synthesis of palmitate
 * 11) All of the following statements relating to  purine nucleotide biosynthesis are correct except:
 * 12) * A – PRPP is a substrate in this metabolic pathway
 * 13) * B – Glutamine forms 2 nitrogen atoms of the purine cycle
 * 14) * C – Formation of N-glycosidic bond only after completion of the base structure
 * 15) * D – Folate cofactors are involved in the carbons of the purine cycle
 * 16) * E – Inosine monophosphate is a precursor of both AMP and GMP.
 * 17) Gout is caused by an excessive increase in the concentration of uric acid in the blood. The cause can be both overproduction and insufficient excretion. A 15N-labeled amino acid can be administered to recognize this situation. Which is best for this purpose?

A patient being treated for acute leukaemia
A 3-year-old girl is diagnosed with acute lymphocytic leukaemia. She received an infusion, allopurinol, day 2 therapy vincristine, prednisone, methotrexate, etc. In 5 days released home. She continued therapy at home (prednisone, allopurinol. Chemotherapy added again in a month. Then she got soor (candidosis) in her mouth, she couldn't eat.

Questions:
 * 1) How do you explain the high level of uric acid (1st examination performed after 5 days of hospitalization, after discharge)?
 * 2) Why was uric acid already normal in future examinations?
 * 3) Why was the urea level 0.7 mmol / l?
 * 4) What other tests will confirm this finding?

Related articles

 * Disorders of ureagenesis
 * Antiuratics
 * Arthritis uratica