Nelson's syndrome

Very rare hypophysis adenoma occurring in patients post adrenalectomia that exaggeratedly produces ACTH. Due to the adrenalectomia there is no feedback inhibition of CRH by cortisol. Therefore, CRH secretion in hypothalamus is increased and subsequently ACTH is overproduced as well.

The very first symptoms are usually loss of vision and hyperpigmentation.

Související články

 * Hypotalamo-hypofyzární systém