Albumin

Albumin is a serum protein that accounts for 55–65% of total serum protein (the average plasma albumin concentration is 40 g/l ). It is synthesized in the liver and its formation depends on the intake of amino acids.

Albumin:


 * Albumin plays a significant role in maintaining the oncotic pressure of the plsama. Albumin values lower than 20 g/l are associated with the occurence of edema.
 * Performs a transport functions. It transports bilirubin, heme, steroid substances, thyroxine, fatty acids, bile acids, metals, drugs and other substances.
 * It creates the body's protein reserve and serves as a source of amino acids, especially essential amino acids for various tissues. Its concentration decreases with malnutrition. However, serum albumin concentration is not a good indicator of early protein malnutrition, because in amino acid deficiency, albumin catabolism is also reduced and albumin is translocated from the interstitium to maintain adequate plasma levels. The slow decline is also due to a longer half-life and a large body supply. For this reason, it does not reflect the full extent of the nutritional deficit.

Albumin synthesis
Albumin synthesis begins in the nucleus of hepatocytes by transcription of genes into mRNA, which is then secreted into the cytoplasm, where it binds to ribosomes to form polysomes that form preproalbumin. Preproalbumin enters the endoplasmic reticulum where it is converted to proalbumin, the major intracellular form of albumin. Proalbumin is further secreted into the Golgi apparatus, where it is transformed into albumin and immediately excreted from the liver.

Related articles

 * Blood plasma proteins
 * Oncotic pressure