Oxidation of very long chain fatty acids

Oxidation of very long chain fatty acids (more than 18 carbons) takes place in peroxisomes. The first step is catalyzed by flavoprotein dehydrogenase, which transfers electrons to O2 – H2O2  is formed : Oxidation ends with octanoyl-CoA, which is transported from peroxisomes bound to carnitine and goes to β-oxidation. The reactions described above do not lead to the formation ATP.
 * 1) FADH2 from the first step is reoxidized not in the respiratory chain, but by reaction with O2: FADH2 + O2 → FAD + H2O2
 * 2) Peroxisomal catalase decomposes H2O2: 2 H2O2 → 2 H2O + O2

Source
Fontana J., Trnka J., Maďa P., Ivák P. a kol.: Transformation of substances and energy in the cell. In: Functions of cells and the human body : Multimedia scripts. Available online from: