Gastric inhibitory polypeptide

Gastric inhibitory polypeptide (GIP) is a hormone formed from 43 AMK. The hormone is produced by the K cells of the duodenal and jejunal mucosa. Secretion is stimulated by the presence of glucose and the breakdown products of fats and proteins.

Its main effect is to stimulate insulin secretion, so the hormone is also referred to as an insulinotropic glucose-dependent polypeptide. At high doses, GIP suppresses gastric secretory activity and motility. The hormone was named after this effect, although at physiological hormone levels this effect is not manifested.

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 * Gastrointestinal hormones