MCR-1

MCR-1 (mobilized colistine resistance) is a relatively newly discovered gene resistant kolistinu – This is considered an antibiotic of the last choice. MCR-1 is horizontally transmitted by R-plasmids, transfer is possible between different strains of bacteria. He was the first time plazmid SHP45 discovered in 2011 in China in bacteria tribe Escherichia coli In pigs, 2016, veterinary use of collisters was restricted. Since then, he has expanded to another thirty countries around the world.

EscherichiaColi NIAID|náhled|220px|SEM snímek bakterie E. Coli, u které byl poprvé identifikován gen MCR-1

Transfer
Between potential MCRPE (MCR-1 Positive enterobacteria) include species of bacteria Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes. MCR-1 is considered first horizontally portable gene resistant to polymyxin, The MCR-1 transmission occurs through the plasmid of over 64 Kbp with frequencies in the range 10−1 to 10−3. MCRPE were originally detected in livestocks that have overused by collisters, but transferring to humans. Surprisingly, the main risk factor for humans is not exposure to infected animals, but abuse antibiotics in history.

Mechanism of action
The resistance mechanism consists in transmitting the phosphatidylamine residue to Lipid A, which is an endotoxin component (lipopolysacharidu) anchored in outer membrane gram-negative bacteria. Phosphatidylamine in bacteria holds function chaperonu – forms the tertiary structure of membrane proteins. Bacteria with such a modified lipid and have significantly lower affinity to colistin and similar polymyxins.

Related articles

 * Colistin
 * Rezistence na antibiotika