Regulation of ketogenesis

Regulation of ketogenesis takes place at four levels:


 * 1) Hormone-sensitive lipase – lipolysis in adipose tissue.
 * 2) Carnitine acyltransferase I – entry of  fatty acids into mitochondria, where their β-oxidation takes place.
 * 3) Routing of acetyl-CoA from β-oxidation to ketogenesis and not to the Krebs cycle.
 * 4) Mitochondrial HMG-CoA synthase.

A high level of ketone bodies in the blood signals the presence of a large amount of acetyl-CoA. Its consequence is the inhibition of lipolysis.