Endothelin

Endothelin is a peptide produced by the endothelium using an endothelin converting enzyme (ECE) on the endothelial membrane. A representative of endothelins is endothelin-1. Endothelin release is stimulated by angiotensin II, ADH, thrombin, cytokines and oxygen radicals. Endothelin-1 acts as a vasoconstrictor, promotes fibrotization, cell proliferation, cardiac hypertrophy or remodeling, and has pro-inflammatory effects. By blocking its receptors (ETA or ETB) these effects are minimized. Inhibitors of these receptors are called sentanes and are used in pulmonary hypertension therapy.

Related articles

 * Vasoconstriction
 * RAAS
 * Hypertrophy