Artery development

Vasculogenesis

 * Formation of vessels from blood islets;
 * Mesoderm cells induced to transform into hemangioblasts under the influence of FGF2 (Fibroblast growth factor 2);
 * Hemangioblasts in the center of the islets differentiate into hemopoietic stem cells, peripheral into angioblasts (precursors of endothelial cells) under the influence of VEGF (Vascular endothelial growth factor);
 * The first blood islets appear in the 3rd week in the areas of:
 * Extraembryonic splanchnopleura (yolk sac wall)  first occurrence;
 * Extraembryonic somatopleura (chorionic plate);
 * Cardiogenic region;
 * Germinal stem.

Angiogenesis

 * Formation of new blood vessels by budding under the influence of VEGF.

Development of arteries

 * Vasculogenesis results in the formation of a primary watercourse - includes the dorsal aorta' and the cardinal veins';
 * at first we find two dorsal aortas, which later join in the middle part of the embryo, remaining divided only in the anterior and posterior parts;
 * the anterior dorsal aortas are related to the formation of the aortic arches';
 * posterior dorsal aortas give rise to 'aa. iliacae communes.

Aortic arches

 * They connect the saccus aorticus and dorsal aortas;
 * is related to the formation of gill arches - they form in the 4th-5th week;
 * 6 pairs in total, the fifth is rudimentary;
 * they arise gradually – we never find all of them at once in the embryo (by the time the third aortic arch is formed, the first one already disappears).

Derivatives of the aortic arches

 * 1) Aortic arch;
 * 2) for the most part it disappears, the remaining section is a. maxillaris;
 * 3) Aortic arch;
 * 4) * for the most part it disappears, the remaining section is a. stapedia and a. hyoidea;
 * 5) Aortic arch;
 * 6) * a. carotis communis is formed from the proximal section, from which a. carotis externa grows;
 * 7) * from the distal part the proximal part of the a. carotis interna is formed (the distal part of the internal carotid artery originates from the dorsal aorta);
 * 8) Aortic arch;
 * 9) * the right one created the proximal part a. subclavia dextra (the distal part originates from the dorsal aorta and from the 7th intersegmental artery);
 * 10) * arcus aortae is created from the left one;
 * 11) Aortic arch;
 * 12) * rudimental, in 50% of cases it is not created, in 50% it disappears immediately;
 * 13) Aortic arch;
 * 14) * on the right proximal part a. pulmonalis dextra is formed, the distal part disappears;
 * 15) * a. pulmonalis sinistra is created from the left proximal section, from the distal part ductus arteriosus.

Withe the creation of 6. the position of the aortic arch is closely related to n. laryngeus recurrens, which innervates the derivatives of the 6th laryngeal arch:
 * after the descent of the heart, the recurrent laryngeal nerve wraps around the 6th aortic arch and rises to the larynx;
 * on the right, due to the disappearance of the 5th arch and the distal part of the 6th  arch, it turns around a. subclavia dextra;
 * on the left it turns around the ductus arteriosus'.

Ventral branches

 * Aa. vitellinae – merge to form the arteries of the dorsal mesentery of the intestine:
 * truncus coeliacus (supplying the distal section of the foregut);
 * a. mesenterica superior (midgut supply);
 * a. mesenterica inferior (hindgut supply);
 * aa. umbilicales (later backs down from aa. iliacae communes, postnatally as aa. vesicales superiores and ligamenta umbilicalia medialia).

Dorsal branches

 * Aa. intersegmentales (a. vertebralis, aa. intercostales, aa. lumbales, aa. sacrales laterales...);
 * from the 7th intersegmental artery arises a. subclavia (entirely on the left, only the distal section on the right).

Aa. coronariae

 * Originating from the cells of the epicardium;
 * muscle comes from the epicardium and neural crest cells.

Related articles

 * Embryonic septation of the heart
 * Congenital heart defects
 * Critical Congenital Heart Defects