LSD


 * A substance prepared semi-synthetically from ergot alkaloids
 * Its chemical composition is lysergic acid diethylamide
 * Synthesis discovered by chemist Albert Hofmann fi SANDOZ in the preparation of nikethamide in 1943


 * Formerly an experimental drug in psychiatry "Delysid"

Mechanism of action

 * An inhibitor of the peripheral serotonin neuronal system that regulates emotion. The mechanism is also affected by other drugs.
 * LSD has an affinity for different subtypes of serotonin receptors, mainly activates 5-HT2 receptors and acts as an agonist.

Abuse

 * Effective doses on absorbent pads: 25–250 µg
 * Symptoms: hyperactivity, confusion, hysteria, hallucinations, delirium, dizziness

Chronic abuse

 * depression, psychosis, flashbacks
 * mild psychological dependence and the development of tolerance is described

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