Non-alcoholic steatohepatitis

Hepatic steatosis is a condition in which the amount of fat (especially triacylglycerols) in the liver exceeds 5% of its weight.
 * Pathogenesis
 * increased dietary fat intake;
 * increased mitochondrial fatty acid synthesis or decreased oxidation;
 * impaired release of triacylglycerols from the hepatocyte;
 * excess sugars, which are converted into fatty acids;
 * hyperalimentation, diabetes mellitus, Wilson's disease, parenteral nutrition, Reye's syndrome.
 * Clinical picture
 * asymptomatic course or non-specific symptoms: hepatomegaly, abdominal pain, + symptoms of the underlying disease;
 * Diagnostics
 * slightly elevated aminotransferases, hypertension, hypertriacylglycerolemia, insulin resistance;
 * liver ultrasound: increased echogenicity;
 * histological picture (small or large droplet, simple steatosis or steatohepatitis);
 * Therapy
 * elimination of the cause, treatment of metabolic disease.

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