Regulation of the pentose cycle

As already stated above, the pentose cycle is regulated at the level of availability of the coenzyme NADP+. If the result reduced form of NADPH is not pumped out and reoxidized in other metabolic processes, reactions that require the oxidized form of this coenzyme are inhibited. The reduction of NADP+ to NADPH is catalyzed by glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. The synthesis of key enzymes is also induced by insulin. Prolactin does the same during lactation.

Clinical correlation:

Glucose-6-phosphate dehydrogenase deficiency is considered the most widespread enzymatic defect worldwide - the number of affected is estimated at 400 million people (mainly in Africa, the Mediterranean, the Middle East and Asia). One of its consequences is the development of hemolytic anemia (due to disruption of the antioxidant systems of erythrocytes). You can find more detailed information in [http://fblt.cz/skripta/v-krev-a-organy-imunitniho-systemu/4-hemostaza/ the multimedia scripts Functions of cells and the human body, 3. LF UK.] Category: Biochemistry Category: FBLT