Disorders of uric acid metabolism / Questions and case reports

Questions

 * 1) In humans, carbamoyl phosphate is a precursor of biosynthesis:
 * 2) * A – uridine monophosphate
 * 3) * B – Inosine monophosphate
 * 4) * C – urea
 * 5) * D – glutamine
 * 6) vitamin B12 metabolites play a role in
 * 7) * A – Catabolism of fatty acids with odd number of carbon atoms
 * 8) * B – In the formation of acetyl-CoA from pyruvate
 * 9) * C – In the transfer of the CH3- group from the tetrahydrofolate coenzyme to homocysteine
 * 10) * D – In the synthesis of palmitate
 * 11) All of the following statements relating to  purine nucleotide biosynthesis are correct except:
 * 12) * A – PRPP is a substrate in this metabolic pathway
 * 13) * B – Glutamine forms 2 nitrogen atoms of the purine cycle
 * 14) * C – Formation of N-glycosidic bond only after completion of the base structure
 * 15) * D – Folate cofactors are involved in the carbons of the purine cycle
 * 16) * E – Inosine monophosphate is a precursor of both AMP and GMP.
 * 17) Gout is caused by an excessive increase in the concentration of uric acid in the blood. The cause can be both overproduction and insufficient excretion. A 15N-labeled amino acid can be administered to recognize this situation. Which is best for this purpose?

A patient being treated for acute leukemia
A 3-year-old girl is diagnosed with acute lymphocytic leukemia. She received an infusion, allopurinol, day 2 therapy vincristine, prednisone, methotrexate, etc. In 5 days released home. She continued therapy at home (prednisone, allopurinol. Chemotherapyadded again in a month. Then she got soor in her mouth, she couldn't eat.

Questions:
 * 1) Jak vysvětlíte vysokou hladinu kys. močové (1. vyšetření provedeno po 5 dnech hospitalizace, po propuštění)
 * 2) Proč byla kys. močová při příštích vyšetřeních již normální?
 * 3) Proč došlo k hladině urey 0,7 mmol/l?
 * 4) Jaká jiná vyšetření potvrdí toto zjištění?

Related articles

 * Disorders of ureagenesis
 * Antiuratics
 * Arthritis uratica