Hyaline petrification

Intracellular occurrence of hyaline in the form of deposits or droplets, examples:


 * Mallory hyalin – cytokeratin coiled into a ball in the cytoplasm of hepatocytes in alcoholic cirrhosis


 * Councilman's bodies - apoptotic bodies in hepatocytes in hepatitis, tend to be inside the ER (as well as inclusions of α 1 -antitrypsin deficiency ).


 * Crooke's cells – non-cancerous cells in the vicinity of a pituitary adenoma producing ACTH (thus causing Cushing's disease ). They contain spirally coiled cytokeratins in the cytoplasm.


 * Russell bodies – inclusions in the cytoplasm of plasma cells during chronic inflammation (correspond to Ig accumulated in GER). The cell acquires a silky appearance, when it ruptures, the hyaline gets into the extracellular space.


 * Trachoma bodies – in the cytoplasm of the conjunctival epithelium during Chlamydia trachomatis infection, they contain glycogen.


 * Viral inclusions - they are formed either by own viral inclusions or by proteins of cells damaged by the virus, they can be:
 * intranuclear – e.g. in keratinocytes in herpes infections;
 * intracytoplasmic – e.g. in ganglion cells in rabies (so-called Negri bodies ).


 * Dystrophic changes of ganglion cells – in degenerative brain diseases, e.g. Lewy bodies (spherical eosinophilic inclusions in the cytoplasm of ganglion cells, there is a clearing around them, they are larger than the nucleus).

Related Articles

 * Disorders of the intercellular substance
 * Collagen
 * Mucopolysaccharides