Enterotoxins

Enterotoxins are produced by:


 * Bacillus cereus:cerium toxin (highly thermostable) - increases vascular permeability, is a necrotizing "diarrhea syndrome", ingesting heavily contaminated food.
 * Clostridium perfringens (some types): enterotoxin, which is also highly thermostable - increases capillary permeability, "only" accumulation of water and NaCl in the intestinal loops, diarrhea (note: toxin D cl. perf. causing enterotoxemia is not enterotoxin acting in the intestine but lecithinase causing hemolysis).
 * Clostridium difficile: 2 thermolabile toxins - A enterotoxin (aqueous, slightly hemorrhagic diarrhea), B necrotizing cytotoxin (acting concurrently?).
 * Staphylococcus aureus: at food poisoning − enterotoxin, acts as a local neurotoxin - stimulation of visceral receptors → rapid peristalsis, ie rapid emptying, further irritates the CNS emetic center, ie vomiting, may act as a super antigen (like TSST-1), causes shock syndrom
 * E. coli ETEC group: thermolabile and thermostable toxin - causes a disease resembling cholera.
 * E. coli group EHEC: shiga-like toxin or otherwise verotoxin (the gene transmits to escherichiasis bacteriophage).
 * Vibrio cholerae: choleragen, persistent activation of adenylate cyclase, increase of cAMP → transport of ions into the lumen of the intestine, water follows osmotically. The result is escalating diarrhea, at first the stool then leaves only the thin liquid of the image of "rice broth" (mucus flakes). Everything leads to sharp dehydration and death without treatment.
 * Shigella dysenterie: Shiga toxin, acts in the large intestine. It inactivates RNA of ribosomes by intoxicating cells → stop of proteosynthesis → necrosis. Bacillary dysentery however, it is not only the intoxication that causes the shigell's own invasion of the intestinal mucosa. Shiga (like) toxin, when introduced into the blood, is highly specific for epitopes on the renal capillaries glomeruli – binding → netting of fibrin → and development of HUS
 * Plesiomonas shigeloides: enterotoxin is de facto shiga like.
 * Campylobacter jejuni: enterotoxin is cholera like, however, the disease is also due to the bacillus own invasive activity.

Related articles

 * Enterotoxicosis
 * Bacterial gastroenteritis