Glycylcycline

Glycylcyclines represent a new group of antibiotics, that is derived from the tetracycline antibiotic minocycline. The main agent is tigecycline. Tigecycline is a broad-spectrum ATB (effective against Gram-negative, Gram-positive and anaerobic microbes, but not effective against pseudomonas and proteus). Tigecycline is a chemically 9-t-butylglycylamido derivative of minocycline.

Indications
They are indicated for complicated skin and soft tissue infections as well as intra-abdominal infections.

Mechanism
Their mechanism of action is: inhibition of proteosynthesis, (blocking protein translation in bacteria by binding to the 30S ribosomal subunit, blocking the entry of aminoacyl-tRNA molecules into the A site of the ribosome).

Antimicrobial spectrum
It is a broad-spectrum antibiotic, that acts on many clinically important bacteria. Both gram-positive, gram-negative, anaerobic and atypical, including some multidrug-resistant- penicillin resistant Streptococcus pneumoniae, Klebsiella pneumoniae and Escherichia coli, ''Staphylococcus aureus. Of gram - negative bacteria it shows lower susceptibility with Pseudomonas aeruginosa, Proteus mirabilis, Burkholderia cepacia and Stenotrophomonas malthophilia''.

The side effects
The side effects are:
 * nausea,
 * vomiting,
 * diarrhea.

Related articles

 * Antibiotic for the treatment of staphylococcal infection
 * Tetracycline antibiotics
 * Antibiotic resistance