ASLO

ASLO (antistreptolysin titer), is the titre of antibodies against streptolysin O, increases in 3-6 weeks after streptococcal infection and decreases in 6-12 months. For this reason, its use in the diagnosis of acute infection is completely irrelevant. There is only one indication for its determination, namely the suspicion of acute rheumatic fever or post-streptococcal glomerulonephritis. Following skin infections, the antibody titer increases slightly because streptolysin O is already inhibited in the skin. Streptolysin O (SLO) is a substance produced by almost all strains of pyogenic streptococcus (as well as group C and G strains). Unlike streptolysin S, it is reversibly inhibited by oxygen - hence the designation O.

Literature

 * PAVELKA, Jan, Pavel HORNÍK a Peter MIKOLÁŠEK, et al. Běžné streptokokové infekce – mýty a omyly. Pediatrie pro praxi [online]. 2011, roč. 12, vol. 6, s. 414-415

Category:Imunology