Post-translational Modifications

Post-translational modifications begin after successful translation. They include:
 * Removing the first Met from the N-terminal of the polypeptide
 * Removal of the so-called signal peptide from the N-terminal
 * in the case of some protein hormones, the resulting peptide molecule is further split - e.g. the formation of insulin :
 * is produced as preproinsulin
 * removal of the signal peptide produces proinsulin
 * after the formation of disulfide bonds, a section of length 31AA - the so-called C peptide - is cleaved from proinsulin
 * the definitive insulin molecule then consists of A and B chains connected in a characteristic spatial arrangement by disulfide bridges

Related articles

 * DNA
 * DNA structure
 * DNA replication
 * Transcription factors
 * Transcription
 * Post-transcriptional Modifications
 * Translation
 * RNA
 * mRNA

Reference


Category:Biochemistry Category:Molecular Biology Category:Genetics