Antifibrinolytics


 * block the binding of plasmin to fibrin

Indication

 * 1) during dental procedures in hemophiliacs
 * 2) during bleeding after surgical interventions (after tonsillectomy) - when replacing coagulation factors

Contraindications

 * in the presence of intravascular coagulation

Side effects

 * vomiting

Principal Representatives

 * Aminocaproic acid
 * per os or intravenously (administer slowly - this will prevent the possible development of shock and intravascular thrombosis)
 * reduces the activation of plasminogen


 * Tranexamic acid
 * the same administration as for aminocaproic acid, but it has a significantly longer effect


 * Aprotinin
 * used for bleeding in fibrinolysis disorders, or in the treatment of pancreatitis


 * p-aminomethylbenzoic acid (PAMBA)

Related Articles

 * Hemocoagulation
 * Hemocoagulation versus anticoagulation
 * Anticoagulants
 * Fibrinolytics