Nephrogenic diabetes insipidus

Nephrogenic diabetes insipidus is a rare inherited disease linked to the chromosome X (mutation vasopressin receptor gene or aquaporin 2 gene).
 * Acquired form much more common: may occur in patients with nephropathy affecting the marrow kidneys + distal tubules ( polycystic kidney disease | polycystic kidney disease, chronic pyelonephritis, etc.), when administration of certain drugs (Li);
 * inability of tubular cells to respond to ADH (normal blood concentration).

Clinical symptoms

 * Polyuria + polydipsia;
 * hypernatremia;
 * hyperthermia;
 * mental retardation.

Diagnostics

 * Dg. determined using a concentration test with exogenous ADH.

Therapy

 * Adequate fluid intake;
 * restrictions Na in the diet, hydrochlorothiazide / indomethacin.

Related articles

 * Diabetes insipidus
 * ADH