Regulation of beta-oxidation of fatty acids

Regulation of β-oxidation takes place at the level of entry of fatty acids into mitochondria – more precisely at the level of the carnitine transporter carnitine acyltransferase I  (CAT I). This enzyme is inhibited by the intermediate product of fatty acid formation - malonyl~CoA. We are talking about the so-called cross regulation. The principle is that fatty acid synthesis takes place in the cytosol, just like the reaction catalyzed by CAT I. Malonyl~CoA is formed as a product of the first reaction of fatty acid formation. Cross-regulation prevents simultaneous synthesis and degradation of MK. Inzulin inhibits β-oxidation, while counterregulatory hormones activate it.

Zdroj
Fontana J., Trnka J., Maďa P., Ivák P. a kol.: Přeměna látek a energie v buňce. In: Funkce buněk a lidského těla : Multimediální skripta. Dostupné online z: