Oxidation of unsaturated fatty acids

Most of the unsaturated fatty acids in the human body and in food have a cis configuration  of double bonds. Their degradation in β-oxidation proceeds by the process described above until their double bond comes into contact with enoyl-CoA hydratase. This requires only trans isomers – it is therefore necessary to convert the cis isomer to trans using an isomerase.

Source
Fontana J., Trnka J., Maďa P., Ivák P. a kol.: Transformation of substances and energy in the cell. In: Functions of cells and the human body : Multimedia scripts. Available online from: