Mental disorders caused by cannabinoids use

Relation to schizophrenia

 * Changes in the endocannabinoid system may contribute to the pathogenesis of schizophrenia.
 * increased activation of the endocannabinoid system through CB1 receptors on GABAergic interneurons in various brain regions -> may lead to hyperdopaminergic and hypoglutaminergic status, which may cause schizophrenia


 * Active ingredient and symptoms
 * tetrahydroxycanabinol (4-THC)
 * Effects: Euphoria, perceptual disturbances, social detachment, impaired judgement,, sociability, lightness, paranoia (i.e. delusions)
 * Withdrawal symptoms
 * Irritability, agression
 * Anxiety
 * Depression
 * decreased appetite (cannabis increases appetite "munchies")
 * insomnia
 * somatic symptoms: headache, tremors, abdominal pain, fever, chills, sweating
 * Mental complications of cannabis consumption
 * Cannabis-induced psychosis (paranoia, delusional thoughts +- hallucinations)
 * Cannabis-induced anxiety disorder
 * Cannabis-induced sleep disorder