Osteaoarthritis Arthrosis

Osteoarthritis also known as arthrosis belongs to the family of arthritic disease. It is a heterogenous group of diseases with common manifestations and findings. Osteoarthritis is a degenerative disease characterized principally by the disintegration of the hyaline articular cartilage paving the way for the damage of the joint and the respective bones.

Epidemiology
náhled|200px|Výskyt OA ve světe v roce 2004 Osteoarthritis affects 250 million patients worldwide with a predilection to the female sex and to the elderly population.

Etiology
There exists two basic forms of Osteoarthritis:


 * 1) Primary Metabolic ; the disintegration of cartilage is a primary, idiopathic, metabolic disorder
 * 2) Secondary Mechanical: the disintegration of cartilage is a secondary mechanical disorder arising from the "wear and tear" of the joint's cartilage or more commonly secondary to mechanical incongruency of the joint prediposed by a variety of disorders including:
 * 3) * Congenital disorders (eg limb hypoplasia, congenital hip dysplasia)
 * 4) * Arthritis (eg Rheumatoid Arthritis, Gout, Septic)
 * 5) * Vascular (eg hemophilia and intrasynovial hemmorrhage)
 * 6) * Infections (eg syphilitic and tubercoulous infections of bones and joints)
 * 7) * Tumors (eg pigmented villonodular synovitis)
 * 8) * Traumas
 * 9) * Endocrine disorders (Mcune Albright syndrome and fibrous dysplasia
 * 10) * Obesity
 * 11) * Bone disorders: Osteoporosis, Osteomalacia, Osteonecrosis

Clinical Picture
náhled|RTG snímek – osteoartróza v typické lokalizaci distálních a proximálních interfalangeálních kloubů ruky

Osteoarthritis does NOT present with the classical Celcius signs of inflammation as Septic arthritis does. However, it is characterized by certain inflammatory changes. When dealing with Osteoarthritis, you'd expect:


 * Pain
 * Joint stiffness and limitation in the range of motion
 * Swollen joint
 * Crepitus sound upon palpation
 * Upon arthrocentesis:
 * Clear non-putrid non-purulent synovium
 * Less than 2000 WBCs/ul in synovium
 * Upon Blood examination: Inflammatory markers (CRP, ESR, procalcitonin, WBC) are NOT elevated

Radiographic Findings
According to Lawrence and Kellgren, there are 5 important radiographic findings:


 * 1) Joint space narrowing
 * 2) Eburnation; subchondral bony sclerotization
 * 3) Osteophytes formation
 * 4) Joint Synovium thickening and synovial effusion
 * 5) Osteolysis, Osteonecrotic changes and subchondral cyst formation

These findings are usually sequential with the narrowing of the joint appearing early on during the disease and cysts appearing late.

Classification of Osteoarthritis

 * Classification according to severity based ont he above mentioned X-ray findings:

I. narrowing of the joint space

II. narrowing of the joint space, subchondral sclerosis on X-ray, formation of osteophytes

III. narrowing of the joint space, subchondral sclerosis on X-ray, deformation of the joint socket and head, osteophytes

IV. disappeared joint clefts, subchondral sclerosis on X-ray, deformities, cysts, osteophytes

Localization
Osteoarthritis is mostly a localized degenerative disease affecting with particular joints being more likely to be affected than others. These are:


 * 1) Hip
 * 2) Knee
 * 3) Vertebral (Spondyloarthroses,Spondylosis)
 * 4) PIP (Proximal Inter Phalangeal) joints: Bouchard's Nodes
 * 5) DIP (Distal Inter Phalangeal) joints: Heberden's Nodes

Pathogenesis

 * Early changes of the disease are characterized by the microscopic and histological changes seen at the level of the articular hyaline cartilage; necrosis of chondrocytes, drying of cartilage, disintegration of collagen type II fibers...
 * The loss of cartilage exposes the bony surfaces and upon motility, the bony surfaces rub against one another. This explains the stress induced eburnation and osteophytes production.
 * The loss of cartilage and the degenerative bony changes irritates also the synovium resulting i synovitis and joint effusion.
 * Terminal results include the necrosis of bone manifested by cystic changes subchondrally.

Diagnosis
Diagnosis is done by combining the clinical and radiographic findings.

Léčba
náhled|Totální endoprotéza v kyčli



Prevence

 * U všech sekundárních artritid odstranění příčiny;
 * screening kongenitálních dysplasií kyčlí u novorozenců;
 * omezení meniskektomií;
 * korigování nestejné délky končetin;
 * léčba synovitidy;
 * udržování přiměřené tělesné hmotnosti;
 * předcházení dlouhodobému jednostrannému přetěžování určitých kloubů;
 * při lehkém počátečním postižení (tzv. preartróza) pohyb, nejlépe plavání či jízda na kole.

Souhrnné video
náhled|střed|upright=1.8|Video v angličtině, definice, patogeneze, příznaky, komplikace, léčba.