Clozapine

 was the first atypical antipsychotic. It belongs to the group of multireceptor antagonists (MARTA). It is mainly used in the treatment of schizophrenia, where two or more types of antipsychotics have already failed, i.e. in drug-resistant schizophrenia. In addition, it is also used in the treatment of schizoaffective diseases and reduces the risk of suicide. However, it is not the drug of first choice.

Indication
It is used in people suffering from schizophrenia and Parkinson's disease because, unlike typical antipsychotics, it does not cause extrapyramidal side effects. However, the comorbidity of Parkinson's disease and mental illness is rare, so it is more likely to be used in the treatment of mental disorders induced by L-dopa. Quetiapine is preferable because it does not cause agranulocytosis.

Side effects
Unlike typical antipsychotics, the risk of tardive dyskinesia is around 0.005%. Its side effects include agranulocytosis (1-2% of cases), orthostatic hypotension, anticholinergic effects, and weight gain.

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