Tromboembolic disease

Thromboembolic disease refers to a group of thrombophilic conditions and their consequences:
 * arterial thrombi and embolisms,
 * thrombophlebitis,
 * deep vein thrombosis, post-phlebitic syndrome, pulmonary embolism,
 * DIC,
 * mesenteric vascular occlusion.

In a narrower concept, thromboembolic disease is mainly understood as deep vein thrombosis (deep vein DK) and its complications (pulmonary embolism, post-phlebitic syndrome).

Pathophysiology

 * Virchow's trias - wall damage, slowing of blood flow, hypercoagulability,
 * thrombosis begins with platelet adhesion, fibrin deposition - white thrombus,
 * a white thrombus can close the lumen, and stagnant blood forms a red thrombus,
 * thrombosis stimulates inflammation in the wall leading to fibroblastic organization of the thrombus - after a few weeks, spontaneous recanalization may occur, but the valves remain damaged.

Related articles

 * Pulmonary embolism
 * Heparin
 * Leiden mutation
 * Thromboembolic disease in gynaecology
 * Thromboembolic disease (paediatrics)
 * Migratory thrombophlebitis