Disturbances in water management in the body

Disorders of water metabolism
The loss or excess of water in the body causes pathologies that are called dehydration or hyperhydration.

Dehydration

 * From reduced supply:
 * lack of water,
 * restriction of reception,
 * impossibility of receiving fluids (coma, swallowing disorders, lack of care for the affected).


 * From increased losses:
 * Skin: sweating, fever,
 * Lungs: hyperventilation,
 * Kidney: diabetes insipidus renalis, osmotic diuresis, insufficient concentration ability, hypokalemia, hypercalcemia,
 * Gastrointestinal tract: diarrhea, vomiting,
 * Lack of ADH.

Hyperhydration

 * A consequence of primary renal impairment
 * Acute renal failure,
 * Terminal renal insufficiency,
 * Obstruction of the urinary tract,
 * Extracellular volume deficit,
 * Circulatory collapse.


 * From increased ADH activity:
 * Cardiac insufficiency,
 * Insufficiency of the liver,
 * Postoperative conditions,
 * hypothyroidism,
 * Brain damage,
 * Carcinoma.

Hyper-osmolility
The causes of hyperosmolality include loss of body water, acute catabolism (e.g. in shock there is an accumulation of intermediate metabolites in the cell that cannot be removed from the body – this results in hyperosmolality of ICT compared to ECT, which further results in the transfer of water to ICT. A decrease in the volume of ECT then aggravates the primary condition, i.e. it intensifies the circulatory disorder). Hyperosmolality may also occur iatrogenically during infusion therapy and parental nutrition (administration of hypertonic solutions, application of glycerol compresses or transcutaneous absorption of propylene glycol in the treatment of burns). These small molecules, when absorbed, increase osmolality. This can be seen from the difference between the osmolality calculation and the value of its determination by osmometry (the so-called "osmolar gap").

Calculation of S-osmolality = 2&thinsp;×&thinsp;Na+ + glucose + urea (all in mmol/l), eg. 2&thinsp;×&thinsp;140 + 5 + 5 = 290 mmol/l

Hypo-osmolality
The causes of this condition include excessive water supply, swallowing water during drowning, compensation for water and salt losses only with water or solutions without electrolytes, inadequate secretion of ADH, metabolic response to trauma, chronic catabolism

With damage to the brain and spinal cord in some cases, severe osmoregulation disorders occur : diabetes insipidus may develop due to the absence of ADH secretion, which accompanies polyuria, increasing osmolality in plasma (up to 330 mmol/kg) and low osmolality in the urine. Another possibility is the development of inadequate secretion of ADH, which leads to hyponatremia and hypoosmolality. Serum osmolality is lower than urine osmolality. Patients face the threat of cerebral edema.

The adjustment of significant changes in osmolality should not occur faster than 2–4 mmol/kg/h and the change in 24 h should not exceed 20–30 mmol/kg.g.

Related articles
Other chapters from the book MASOPUST, J., PRŮŠA, R.: Pathobiochemistry of Metabolic Pathways:
 * Water management disorders
 * Parameters of water management
 * Dehydration

Source
Category: Pathobiochemistry
 * Reprinted with the permission of the author from the https://uloz.to/!CM6zAi6z/biofot-doc
 * MASOPUST, Jaroslav and Richard PRŮŠA. Pathobiochemistry of metabolic pathways. 2nd edition. Charles University, 2004. 208 pp. pp. 170–171.