Pemphigoid



Pemphigoid has the similar clinical manifestations as pemphigus, but blisters are not determined by the acantholysis and are subepidermal. The prognosis is more favorable, treatment – corticosteroids and immunosupressive drugs.

Bullous pemphigoid
Parapemphigus or senile pemphigus is an autoimmune disease. Most offenly occurs in older people (70–80 years old). Spolehlivé odlišení od bulózního pemphigu je možné jen histologicky. Puchýře na lehce zanícené spodině, na končetinách, později na trupu, symetricky; zanechávají pigmentace. Nikolsky's sign is negative. The course of the disease is prolonged, může dojít ke spontánní remisi. Sometimes it occurs as paraneoplasia or after a drug treatment (penicillin, furosemide, Brufen…).

Benign mucosal pemphigoid
For scarring pemphigus is typical je typický tvorbou IgG a IgA proti BM s depozity C3. It affects conjunctiva, nasal cavity, pharynx, larynx, nose, genitals, anus. Heals with a scar, při postižení oka může způsobit slepotu, zanechává stenózy. Occurs rather in older individuals.

Related articles

 * Oční cikatrikózní pemphigoid
 * Pemphigus