Inversion

Inversion is a form of chromosome mutation – structural abnormality.

• Typical for inversion is two breaks in different parts of the chromosome. The newly created segment rearranges itself and is reversed.
• Inversion was discovered in 1921.
• Although we still don´t know why inversion exists, we know that it is the most important mechanism of reorganizing the genome.
• We recognize 2 types of inversion:

1. pericentric – causes deletions, insertions or abnormal centromeres, with a breakpoint in each chromosomal arm.
2. paracentric – is the more common type, it is less harmful for its carrier as it does not involve the centromere.

• Inversion suppresses the recombination process.

Contents 1 Links 1.1 Related articles 1.2 Sources 1.3 Bibliography

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• Chromosome Abnormalities
• Karyotype

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• How and Why Chromosome Inversions Evolve

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• KUMAR, ABBAS, FAUSTO, MITCHELL,, et al. Robbins Basic Pathology. 8th edition edition. 2007. ISBN 978-0-8089-2366-4.