Inversion

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Paracentric inversion
Pericentric inversion

Inversion is a form of chromosome mutationstructural abnormality.

  • Typical for inversion is two breaks in different parts of the chromosome. The newly created segment rearranges itself and is reversed.
  • Inversion was discovered in 1921.
  • Although we still don´t know why inversion exists, we know that it is the most important mechanism of reorganizing the genome.
  • We recognize 2 types of inversion:
  1. pericentric – causes deletions, insertions or abnormal centromeres, with a breakpoint in each chromosomal arm.
  2. paracentric – is the more common type, it is less harmful for its carrier as it does not involve the centromere.
  • Inversion suppresses the recombination process.


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  • KUMAR, ABBAS, FAUSTO, MITCHELL,, et al. Robbins Basic Pathology. 8th edition edition. 2007. ISBN 978-0-8089-2366-4.