DaTSCAN

From WikiLectures

DaTSCAN is a diagnostic method to investigate if there is a loss of dopaminergic neurons in striatum. Its principle is based on using of radiopharmaceutical, which bind to dopamine transporters (DaT). The signal from them is then detected by the special gamma-cameras and the picture (SCAN) is created.

DaTSCAN is indicated in cases of tremor in patients, when we are not sure about its origin. Althought this method can distinguish essential tremor from Parkinson´s syndrome, it is unable to show us if the problem is Parkinson´s disease, multiple system atrophy or progressive supranuclear palsy.

Its main advantage is that DaTSCAN is able to diagnose Parkinson´s disease much earlier – in stage of 30% loss of the dopamine brain cells instead of 80-90% [1], when the symptoms are already so visible, that we can be sure about the diagnosis. The earlier diagnosis, the earlier treatment with better results.

Striatum
Dopamine Pathways
Dopamine D2 receptors
Gamma-camera


How It Is Done?[edit edit | edit source]

At the beginning a patient should take two iondine tablets and wait for one hour. These pills are highly important, because they prevent the accumulation of radioactive substances in thyroid gland! After one hour, the patient gets an injection to shoulder, which contain the radiopharmaceutical and then he has to wait for 4 hours. The concentration of the substance increases and then it is scanned by gamma-camera, which is located around his head. Whole examination lasts about 30-45 minutes and it is non-invasive.

If a patient use some of the medication listed below, it is necessary to stop the using few days or weeks before the DaTSCAN, but just after a consultation with his doctor.

The examination takes just a few hours, so patients needen´t to stay in a hospital overnight, but they have to drink much more than they are used to and go to the toilet more often. It is important for a fast elimination of the radioactive substances from the body.


Contraidications[edit edit | edit source]

  • pregnancy
  • breast-feeding
  • severe renal or hepatic insuficience
  • allergy to iodine substances
  • some kind of medication – stimulants or noradrenalin and some antidepressants


Differential Diagnosis[edit edit | edit source]


Links[edit edit | edit source]

Related articles[edit edit | edit source]

External links[edit edit | edit source]

References[edit edit | edit source]

  1. [1]