Ascites

Ascites is an accumulation of (usually) noninflammatory fluid in peritoneal cavity. It is one of the consequences of liver cirrhosis. All the patients with ascites usually have liver cirrhosis (or other liver fibrosis) and portal hypertension.^[1] The peritoneal cavity contains physiologically 150 ml of fluid^[2] produced by mesothelial cells, larger volume is considered as ascites. 10 liters of fluid is no exception.

Contents 1 Patophysiology 2 Diagnostic and clinical features 3 Therapy 3.1 Conservative therapy 3.2 Invasive therapy 4 Other causes of ascites 5 Links 5.1 Related articles 5.2 References

edit Patophysiology

Formation of ascites is a mutifactorial process. There are several theories (several factors) about its formation:

• sodium and water retention - is renal dysfunction (higher reabsorption of Natrium in renal tubules), it causes formation of swelling and ascites;
• hypoalbuminemia with reduced plasma oncotic pressure can be a reason for migration of fluid from plasma to extravasal space and peritoneal cavity;
• vasodilatation in splanchnic circulation - mediated by nitride oxide, it causes larger blood volume to splanchnic circulation;
• portal hypertension - higher resistance in liver sinusoids supports migration of fluid to extravasal space in liver, their lymphatic veins can drain away only a part of this fluid;
• baroreceptor-mediated stimulation of renin-angiotensin system and maybe more...^[1]

edit Diagnostic and clinical features

• physical examination - increasing abdominal girth, percussion - undulation of fluid (fluid wave), "caput medusae" - dilated subcutaneous veins of abdomen, shortness of breath - because of elevation of the diaphragm, dyspepsia;
• USG - is the most basic diagnostic method;
• lab - signs of liver cirrhosis (elevation of AST and ALT, hypoalbuminemia, decrease of coagulation factors produced by liver, increase of INR), increase of Natrium.

edit Therapy

edit Conservative therapy

• diet - salt restriction, < 3 g of salt per a day^[2];
• diuretics:
  • spirinolactone to 400 mg/day (natrium and water elimination)^[2];
  • furosemid 160 mg/day (water elimination)^[2];
• nonselective β-blockers - propranolol, nadolol (portal hypertension therapy)^[1].

edit Invasive therapy

Invasive therapy is for patients with refractory ascites.

• paracentesis - usually 5 l of fluid or all the fluid (often paracenthesis is risk of infection)^[2], 200 ml of fluid should be used for laboratory and hematological examination (exclusion of peritonitis...)^[1];
• TIPS - transjugular intrahepatic porosystemic shunt;
• surgical portocaval shunt (but TIPS is prefered).

edit Other causes of ascites

• Budd-Chiari syndrome (trombosis of hepatic veins);
• heart failure;
• kwashiorkor;
• peritoneal carcinomatosis;
• pancreatitis.

edit Links

edit Related articles

• Cirrhosis
• Portal Hypertension
• Esophageal Varices

edit References

1. ↑ ^{a b c d} KASPER, Dennis L – FAUCI, Anthony S – LONGO, Dan L, et al. Harrison's principles of Internal Medicine. 16th edition. New York : McGraw-Hill Companies, Inc, 2005. 2607 pp. pp. 1892-1896. ISBN 0-07-139140-1.
2. ↑ ^{a b c d e} ČEŠKA, Richard, et al. Interna. 1. edition. Prague : Triton, 2010. 855 pp. pp. 433-434. ISBN 978-80-7387-423-0.